Awor, you should contact Droit. We had an extensive list at one point looking at all of these data points for methylation and detox pathways.
I got the list thx moonman - it was in a spreadsheet on solve (unless this is a different one)
We had this one saved on OneDrive. Can you post the one you found, I know I had a number of different spreadsheets.
I’ve sent you a private msg
Hey guys, an update on this project. @awor and myself just had a great call with @Ghost and I’m really pleased we’ll be working on this together.
Please request and download your raw data from 23andme.
This comes in the form of a text file around 15 megabytes, and shortly we’ll be devising a way for you to get this to us. There’s a button in your 23andme account to request this. Anyone who hasn’t yet and wants to do a 23andme is welcome to do so (if they can afford it) to contribute to this dataset.
Thanks
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Added 23AndMe to the community campaigns page.
Have ordered one myself and will send the results over.
Let’s keep this thing rolling guys 
Anyone who orders one - you’re a champ!
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So it is the 23 and me plus health test we need to order? They have one that is 69 and the health 139$ now I believe…
I don’t know if these 23andMe test results are accurate you guys. Might be a waste of time and a money grab from the companies doing them.
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If you live in the US, you get the whole test. Outside the US, you get only the smaller one (just files). This files can be analysed through different online platforms to be found in this thread. Best
At least in the PSSD research side of things, we’re only interested in the .txt raw data. Paying the extra money gets you the exact same data recorded, but you also have access to a lot of 23andMe’s proprietary research that will tell you anything from how tall you should be to if you are likely to go bald. For me, those things aren’t what we’re looking for, and are maybe a waste of money. It’s usually those trait facts that are incorrect and not the genotyping itself.
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Promethease offers a health report that is perhaps even better than the one 23andMe offered (as of 2014) and it only costs $12.
Never found much evidence of 23andMe being erroneous, and believe me, I went looking for information on error rates after this: 23andMe Test and Cystic Fibrosis Gene
All sorts of different sources quote different error rates, but it appears to fall between 0.01% and %1.0, in the material I have seen, with a vast majority of the references citing numbers toward the lower end, between 0.01% and 0.05%. Most of the high error rates were attributed to poor handling of DNA samples or a just-plain-bunk probe for some of the SNPs. Pretty reliable for a ~$100 test, if you ask me.
In fact, the SNP genotyping they do is generally considered more accurate than whole-genome sequencing alone, which costs ~$1000. If ever considering whole-exome sequencing, save your money for something better.
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Hey Awor,
i know, this is very speculative, but do you think, that IF (a very very big IF) the MTRR A66G Gene is the root cause of our problem, it would potentially be solveable with CRISPR?
I have 23andme Data as well and will provide.
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I’m aware of the conflicting information over the accuracy of DTC tests, but it’s accurate enough for the programmatic correlation we’re interested in doing. We believe it’s worthwhile for those with the data to share it, and if any more members want to have it done to contribute more data then that’s great.
As @Ghost says we’re interested in the raw .txt file and will post a way for users to get that to us soon, so if previous posters can grab it in the meantime that would be helpful.
There is precedent for such data being used in attempts to predict drug responses:
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@axolotl Do you know if it’s possible to get the .txt file with only the “ancestry” 23andme option or would one need to purchase the full health report? Also, I’m assuming there’s no problem getting the .txt file as a uk user? Someone suggested above that US users have access to more data. Thank you.
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Yes, the .txt file is acquirable with just the ancestry (cheaper) option, which is what we want. In terms of the differences, the only differences I’m aware of is some few changes to the genes checked between their different chip versions, but the majority should be the same.
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Let me know if there a dropbox or something i can send my results to.
Just to carify: Are you only asking those who have already done the test or plan to test anyway to provide their data? Or do you think everyone should do it to provide more data?
I have not done the test and I don’t plan to. However, if you guys think it is a worthy investment of funds I’d be happy to do it. How important is this, and how confident are you guys that this will yield helpful results?
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@Ghost, @axolotl and myself had a good talk this past weekend. We agreed to closely work together on a Genome-wide association study (GWAS) across all patient groups encompassing PFS, PSSD, PAS (Accutane) and possibly Lupron/GnRH analogs (if we can involve that group). We will be using high powered software and computing resources to perform what basically amounts to a scientific study, executed at the community level. We are hoping to find genetic variants which predict our condition, and possibly find similarities between our respective conditions at a genetic level. Of course, we hope that this information will help us and our scientists better understand what the genetic drivers may be that make us more susceptible to this/these syndrome(s) than others. If we do find something interesting, we will try to recruit a scientist to help us deepen our investigation and publish the results in a peer reviewed journal.
Now we need YOUR HELP: If you already have taken a 23andMe test, please download extract and rename your provided file so it is called
username_substance_23andme.txt
for example, mine would be called:
awor_finasteride_23andme.txt
This will help us track who is providing the data. Please then upload your raw data to the following link:
Please note that only you and us can see your uploaded data. You will also not be able to see the uploaded data of other users. If you do not already have 23andMe genomic data, please consider getting yours tested through the 23andMe service.
Thanks in advance for your support.
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Thanks Awor and the others for the work. I will do the test after my vacations and will uodate the data.
Regards.
Would it be worth getting the more expensive version to see how your current health is or if your prone to any conditions? Standard is €99 and advanced is €169