23andMe Results


#1

Hello everyone,

I don’t see a common place for 23andMe results, so I’ll put mine here.

Maybe we can start to see some similarities between results.

Attached is a Detox profile, and a Methylation profile.

The Detox and Methylation profiles are from Genetic Genie (geneticgenie.org).

I used them because 23andMe can’t currently include their health analysis in the results they give.

The attached Methylation profile has some brief explanations regarding my mutations.

I also have the “raw” data from 23andMe, but didn’t upload it because the file is around 15 MB (it was taking forever).

Anyway, here’s a summary:

Methylation Profile Results:

homozygous mutations (++)

VDR Taq
MAO-A R297R
BHMT-02
BHMT-08

heterozygous mutations (±)

COMT V158M
COMT H62H
MTR A2756G
MTHFR C677T
MTHFR A1298C   
MTRR A66G
MTRR A664A
CBS C699T

Detox Profile Results

homozygous mutations (++)

SOD2 A16V
NAT2 R197Q

heterozygous mutations (±)

CYP1A2 164A>C
CYP1B1 L432V
CYP1B1 R48G
CYP2D6 S486T
CYP2D6 100C>T
CYP3A4*1B

If anyone knows how I can get more results from my raw data please let me know. Also, if someone knows where I can get information in layman’s terms for my results that would help. Thanks.
Detox Profile Results _ Genetic Genie.doc (109 KB)
Methylation Results _ Genetic Genie.doc (121 KB)


#2

Hi everyone, I’m posting my data which I just got from 23andme.

Heterozygous (+/-) for:
MTHFR C677T
COMT V158M
COMT H62H
MTR A2756G
MTRR A66G
BHMT-02
BHMT-08

Homozygous (+/+) for:
VDR Taq
MAO-A R297R

COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CC -/-
VDR Taq rs731236 AA +/+
MAO A R297R rs6323 T +/+
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 TT -/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 AG +/-
MTRR H595Y not found n/a n/a
MTRR K350A rs162036 AA -/-
MTRR R415T not found n/a n/a
MTRR A664A rs1802059 GG -/-
BHMT-02 rs567754 CT +/-
BHMT-04 not found n/a n/a
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 TT -/-
AHCY-02 not found n/a n/a
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 – no call
CBS N212N not found n/a n/a
SHMT1 C1420T not found n/a n/a


#3

Thanks xptriado,

Can you please go to https://geneticgenie.org/detox-profile/ and do the Detox profile as well?


#4

what is this?can you explain in simple words?


#5

I just want to say that I have probably found where my spasms come from and its not from GABA-A. After I saw this data and correlated with the medication which gave me epileptic FITS when I was young, I found out it was an anti-dopaminergic, I think my spasms are coming from a dysfunctional vitamin D receptor…

These are the results from the detox profile

Heterozygous (+/-) for:
CYP1A2 164A>C
CYP1B1 L432V
CYP1B1 N453S
CYP1B1 R48G
CYP2D6 2850C>T
NAT2 I114T

Homozygous (+/+) for:
SOD2 A16V
CYP2D6 S486T

GSTT1 is Present

Has anyone here tried Mucuna Pruriens?


#6

btw, how surreal is it that we share the same homozygous at VDR taq and SOD2?

What are your symptoms? Do you have muscular spasms at night?

Here you can retrieve more info mthfrsupport.com/reports-con … r-reports/

Look at this guy’s blog, you’ll see how much more info you can get for 20bucks. howirecovered.com/my-genetics/


#7

I am quoting a person’s analysis of my mutations on another site.
It’s very interesting as I think it can provide insight into my cheek/lip bitting since a kid, sleep myoclonus, seizures after a medication i took, and to my gynecomastia early in propecia treatment, and it’s persistency after i stopped the drug.
Have a look.


#8

I’d like to see more people’s results to compare!

I have severe dry eyes, blurry vision, tinnitus, slower thinking, some kind of weird histamine itch attacks, and minor libido issues.

Thanks for the info.

Holy shit, that part about the BHMTs describes me PERFECTLY. I have always bitten my lips and cheeks. They also peel constantly. Also, I am never comfortable sitting for long, especially on the ground. I can just never get comfortable. I have to move my legs a lot. My arms and feet also fall asleep very easily. Not sure if that is related.

We all seem to have Vit D issues as well…

The SOD2 affects mitochondria…fatigue anyone!!!

We all have some susceptibility that got us here. Millions of guys take Fin without major issues, so we HAVE to have something in common that caused us not to be able to compensate for what the drug does.


#9

hey! we have many identical mutations on some key points.

I want to ask you, if you find more coincidences in my symptoms:

  • Tenderness in nipples during first weeks of finasteride usage, which then turned into gynecomastia?
  • Insomnia and Unrefreshing sleep?
  • Muscle twitches?
  • Epilepsy fits
  • Sleep Myoclonus and Involuntary movements during night and sometimes during day?
  • Is your skin very light and do you get burned easily by sun?
  • In your family, do some neurological diseases run? In mine there is history of some sort of epilepsy, barely noticeable, and anxiety, insomnia and depression (undiagnosed).
  • Lip bitting you already told me you have.
  • Numbing feeling on legs?
  • Anyone with PTSD in your family?
  • Lack of motivation.
  • Low libido or what seems to be some kind of reduced need for sex.
  • Twitchy eye lids.
  • TCA’s, Tetracyclics, 1st generation anti-histamines lead to Sleep Myoclonus and Limb movement.
  • Tendency towards depression…but it’s manageable through sports and surrounding with people.
  • Did you get rare side effects from other meds? Which side effects from which meds?

Thank you!!


#10

Results from Sterling App in MTHFR Support website:

u[/u]

Detox
CYP2D6 S486T G GG +/+
SOD2 A16V G GG +/+
SOD2 A AA +/+

Allergy/Mold
CD14 C CC +/+

IgA
HLA-DQA2 A AA +/+

Clotting Factors
SERPINC1 T TT +/+

Methylation
AGT M235T/C4072T G GG +/+
CBS A13637G T TT +/+
MAO A R297R T T +
MTHFS C CC +/+
NOS3 A AA +/+
NOS3 G GG +/+
PEMT A AA +/+
SHMT2 A AA +/+

Mitochondrial Function
NDUFS7 A AA +/+
NDUFS7 T TT +/+
NDUFS7 T TT +/+

u
Detox[/u]

CYP2D6 T2850C A AG +/-
CYP1A2 C164A C AC +/-
CYP1B1 L432V C CG +/-
CYP1B1 N453S C CT +/-
CYP1B1 R48G C CG +/-
NAT2 G590A (R197Q) A AG +/-
PON1 Q192R C CT +/-
SOD2 T CT +/-

Tongue Tie/Cleft Palate
CTH S4031I T GT +/-
IRF6 A AC +/-
IRF6 A AG +/-

Allergy/Mold
HLA C CT +/-
FCER1A C CT +/-

IgC
FCGR2A A AG +/-
GSTM3 V224I T CT +/-

IgA
TRAF1 G AG +/-
IGF1R A AG +/-
IFIH1 (HLA) C CT +/-
CFH A AG +/-
MTC03P1 C CT +/-
HLA-DPB2 / COL11A2P A AG +/-

Clotting Factors

CETP C AC +/-
CYP4V2 C AC +/-
HRG T CT +/-

Methylation
ACE Del16 G AG +/-
BHMT-02 T CT +/-
BHMT-08 T CT +/-
COMT H62H T CT +/-
COMT V158M A AG +/-
DAO C AC +/-
DHFR C CT +/-
GAD1 C CG +/-
GAD1 C CT +/-
GAD1 A AC +/-
GAD1 T GT +/-
GAD1 T CT +/-
GAD1 T CT +/-
GIF (TCN3) A AG +/-
MTHFD1 C105T C CT +/-
MTHFD1 G1958A A AG +/-
MTHFR C677T A AG +/-
MTR A2756G G AG +/-
MTRR A66G G AG +/-
MTRR G AG +/-
NOS2 A AG +/-
NOS2 T GT +/-
NOS2 A AG +/-
TCN1 G AG +/-
TCN2 C766G G CG +/-

Celiac Disease/Gluten Intolerance

HLA G AG +/-

Thyroid

FOXE1 A AG +/-
FOXE1 A AG +/-

Eye Health

BCMO1 A379V T CT +/-

Mitochondrial Function
NDUFS3 A AG +/-
UQCRC2 T GT +/-

Other Immune Factors
ATG16L1 C CT +/-
IL5 A AG +/-
SULT1A1 G GT +/-
SULT1A1 A AG +/-
SULT2A1 T CT +/-
SULT2A1 C AC +/-


#11

but what all of this mean?


#12

its our genetic data.
we are trying to find patterns among ourselves.
you can order it through 23andme.com, it costs around 150$ with shipping included

Read it here: viewtopic.php?f=27&t=8592&p=81032#p81032


#13

is it home test?


#14

they send you a tube which you fill in with your saliva and send back to them. its very easy.
the price you pay includes shipping from USA and back to USA.


#15

Answers in bold.

It would be great to see more people’s results here…


#16

Hey!

Thank you for answering! Anxieth and some traces kf depression run in my direct family too, and my lip bitting is annoying me since i was a kid.
I had breast lumps at a specific part of my teenagerhood.but then.theh disappeared totally until. Finasteride…
I always had probs being nervous around girls too.

Anyway, im ordering some more supements, namely stuff for the mitochondria, sunflower lecitin for the lip bitting, adenosylcobalamin, and some co factors…

Ill keep yuu posted


#17

This is the analysis of my 23andme data from geneticgenie:

Methylation Profile Results:

Heterozygous (+/-):
MTHFR C677T
MTR A2756G
BHMT-02
BHMT-08
AHCY-01
AHCY-19
CBS C699T

Homozygous (+/+):
COMT V158M
COMT H62H
VDR Taq
MTRR A66G
MTRR A664A

Detox Profile Results:

Heterozygous (+/-):
CYP1A2 164A>C
CYP1B1 R48G
CYP2C93 A1075C
CYP2C19
17
GSTP1 I105V
NAT2 I114T

Homozygous (+/+):
CYP1B1 L432V
CYP1B1 N453S
NAT2 K268R

For anyone else who has 23andme data, run it through geneticgenie.org (it’s free) and post the results here.


#18

can we change the subject of the thread to MTHFR Gene Mutation?
23andMe does not make any sense.


#19

It’s a thread for people’s 23andMe results. The fact that we are all showing MTHFR mutations is a coincidence. In fact, the thread was started to see what similarities we may share.


#20

I was talking with my doctor recently about this genetic data and he mentioned that I probably have one of the “bad” APOE gene variations.

I checked later on 23andme and sure enough I have APOE 3/4 - which is not the worst one, but still bad.

It’s pretty new science but apparantly this gene variation increases the risk of Alzheimers - I’m not sure how it might relate to PFS but could be another data point to compare.

To find out your status visit this page:
23andme.com/you/journal/alz … echreport/
(you have to click a button to “unlock” the info)