Actually seizures are on the list of methylation based diseases. Sleep and mental health issues also fit. See the Methylation Made Easy video #1 linked in my signature.
The way that stress fits in is, stress depletes B vitamins. So if you’re already low or borderline in B vitamins, episodes of stress can cause symptoms because you don’t have enough B vitamins on board to deal with it.
You have the B12 Double Whammy - both MTR (B12 intake) and MTRR (B12 recycling). You may be deficient in and need to supplement with B12. Unfortunately, testing is not always accurate. If you’re low, you’re low. But if it’s high or normal, you could still be low.
There are many signs and symptoms of B12 deficiency though. This is a great article: chriskresser.com/b12-deficiency- … nsequences
For your COMT/VDR mutations, Yasko suggests all three types of B12 (hydroxycobalamin, methylcobalamin and adenosylcobalamin) with less methylcobalamin.
The VDR Bsm could make you low in Vitamin D which would affect mood. You can test for this and supplement if you’re low.
MTHFR C677T could lower your levels of methylfolate.
Shawn Bean from MTHFRsupport.com has mentioned that those with BHMT mutations could have the wiggling foot or leg, lip chewing and so forth, where a person never feels relaxed and they end up doing these repetitive behaviors as a result. I actually have the same thing - BHMTs, foot wiggles, cheek chewing.
For the BHMTs, Yasko suggests sunflower lecithin, which would provide TMG (tri methyl glycine). If you look at a methylation cycle diagram, BHMT is in the secondary shortcut methylation pathway.
CYP1A2 - slow caffeine metabolizer
CYP1B1 - could cause estrogen dominance which can cause estrogen related cancers (breast, cervical, etc. for women and prostate for men). You can eat cruciferous veggies, or take DIM or IC3 supplements if your estrogen is running high.
CYP2D6 - detoxifies 20% of all prescription drugs including psych drugs - could have problems with those - see the Detoxigenomics link in my signature for a complete list of drugs. I found a study which says Metoclopramide is metabolized by CYP2D6 - ncbi.nlm.nih.gov/pubmed/24010633
NAT2 - slow detoxifier of smoke and petrochemicals - so avoid those
SOD2 A16V - affects mitochrondria, so could affect energy. You can try a GliSODin supplement or take mitochondrial supplements such as ribose, carnitine, CoQ10, etc.
GSTT1 is Present - if this were absent, you would have worse problems with glutathione than those possibly caused by your MTHFR/MTR/MTRR mutations. So that fact that it’s present is good.