Checked yesterday night and im e3/e3, so the most common
COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CC -/-
VDR Taq rs731236 AA +/+
MAO A R297R rs6323 G -/-
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AA +/+
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 TT -/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 AG +/-
MTRR H595Y not found
MTRR K350A rs162036 AG +/-
MTRR R415T not found
MTRR A664A rs1802059 GG -/-
BHMT-02 rs567754 CC -/-
BHMT-04 not found
BHMT-08 rs651852 TT +/+
AHCY-01 rs819147 CT +/-
AHCY-02 not found
AHCY-19 rs819171 CT +/-
CBS C699T rs234706 AA +/+
CBS A360A rs1801181 GG -/-
CBS N212N not found
SHMT1 C1420T not found
Profile: Methylation Profile
CYP1A12C A4889G rs1048943 TT -/-
CYP1A1 m3 T3205C rs4986883 TT -/-
CYP1A1 C2453A rs1799814 GG -/-
CYP1A2 164A>C rs762551 AA -/-
CYP1B1 L432V rs1056836 GG +/+
CYP1B1 N453S rs1800440 TT -/-
CYP1B1 R48G rs10012 CC +/+
CYP2A62 1799T>A rs1801272 AA -/-
CYP2A620 rs28399444 II -/-
CYP2C92 C430T rs1799853 CT +/-
CYP2C93 A1075C rs1057910 AA -/-
CYP2C1917 rs12248560 CC -/-
CYP2D6 S486T rs1135840 CG +/-
CYP2D6 100C>T rs1065852 GG -/-
CYP2D6 2850C>T rs16947 AG +/-
CYP2E11B 9896C>G rs2070676 CC -/-
CYP2E11B 10023G>A rs55897648 GG -/-
CYP2E14 4768G>A rs6413419 GG -/-
CYP3A41B rs2740574 TT -/-
CYP3A42 S222P rs55785340 AA -/-
CYP3A43 M445T rs4986910 AA -/-
CYP3A4*16 T185S rs12721627 GG -/-
GSTP1 I105V rs1695 AA -/-
GSTP1 A114V rs1138272 CC -/-
SOD2 A16V rs4880 AA -/-
NAT1 R187Q rs4986782 GG -/-
NAT1 R64W rs1805158 CC -/-
NAT2 I114T rs1801280 CT +/-
NAT2 R197Q rs1799930 GG -/-
NAT2 G286E rs1799931 GG -/-
NAT2 R64Q rs1801279 GG -/-
NAT2 K268R rs1208 GG +/+
You have none or hardly any -/-. That may be a problem.
I have noticed that most of your share SNPs with me;
MTHFR C677T (the godfather), CYP1B1(estrogen dominance), COMT (High Dopamine and Adrenaline), VDR Taq(low Vit D), BHMT-08
I have noticed that most of your share SNPs with me;
MTHFR C677T (the godfather), CYP1B1(estrogen dominance), COMT (High Dopamine and Adrenaline), VDR Taq(low Vit D), BHMT-08
You guys may also want to run your data through Promethease. It gives a highly detailed and specific list of diseases and traits you are at risk for based on the entire list of raw data from 23andme, not just those looked at by Genetic Genie.
Of particular interest to you guys this came up in my Promethease results;
RS6311 C,C
3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants.
Again vdr and methylation…
Do you hsvr blood examd to b12 b9 and D vitamins, and homocysteine?
What about heamograms and white blood cell exams?
ii repeated my red and white blood cell tests, cholesterol, triglicerids and homocysteine.
I was expecting to find high homocysteine but it was very low, 4,95 when range started in 5.00
I’ve been supplementing with adenosylcobalamin for around 4 weeks. So i guess I’m using too much of it and it’s excessively converting it to methionine; or also because of intake of B6, conversion to cysteine is increased; or could be SAH.
Would anyone have experience with this?
Has anyone tried running their results through Promethease? It gives very specific risks associated with all of your SNPS not just those on genetic genie and Sterling’s App.
I have. Promethease gives u a lot of info but i havent found anythibg useful because it will tell you at the same time for snp aaa you have 2x more probabulity of parkinson, but with snp bbbb u have less 3x times probability of parkinson.
I stick to genetic genie, methylation and detox profile, and also mthfrsupport.com has something interestibg…and i also checked if i had any rare snp through some application of someone i. Phoenixrising.
So in phoenix rising i was told to focus onAGT M235T/ C4072T and NOS3
The first is connected to anxiety and the second with late onset insomnia!
I know COMT can also cause anxiety issues esp combined with MAOA. Looks like you have those.
For me, my methylation looks pretty bad, one of the worse ones I’ve seen with homozygous MTHFR, multiple COMT, BHMT, multiple CBS, multiple MTRRs (hetero). Gonna start on the methyl folate and B12. Not sure how noticeable improved methylation is, suppose I will see.
Ive been reading amy yasko book, still not finished. Im makibg a summary, its too much info. Maybe ill post it in a blog…
It seems you should as well cut on some foods and help your gut since its where there is sometimes a lot of inflammation and where serotonin is made for the most part.
If supplementing to bypass your mutations doesnt work maybe you could have a look at the book to see where it could have failed…
Where did you see comt and maoa can lead to anxiety?
Read a lot of Phoenix rising. COMT is related to breakdown of dopamine and MAOA to the breakdown of serotonin. If you have the SNPS you are unable to break them down resulting potentially in anxiety, panic attacks, mood swings.
I’m +/+ for 2 COMTs and can definitely vouch for the anxiety, had it most of my life.
I just wanted to let you guys know how I’m finding important to read this book (it’s free).
Im on chapter 6 of the Amy Yasko book “Autism Pathways to Recovery”, in the first priority mutations.
I think with what I have learned today I can explain already a lot of my problems:
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With a CBS mutation more cysteine is generated, and when the cell detects a high level of cysteine it produces more taurine and less gluthatione. So it’s common in people with CBS upregulations (mutation), to see low homocysteine levels. I have a CBS mutation, A13637G, my Homocysteine was low in my only test done to it and I also didnt feel good when I tried taurine (prob had to do with an already elevated taurine level)
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NOS mutation can exacerbate CBS ammonia problem coming from upregulations, as inneficient NOS activity can lead to lead to elevated ammonia levels on its own. I have NOS3 homozygous mutations and NOS2 heterozygous mutations.
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Ideally, two molecules of BH4 are needed for each molecule of ammonia in order to detoxify it. Increased ammonia will deplete BH4 and BH4 is needed to create nitric Oxide, which means there is a reciprocal impact here. It is also critical in regulating neurotransmitters. Insufficient BH4 will make the body produce peroxy nitrite or super oxide, which can create oxidative stress. So my already reduced nitric oxide from an impaired NOS2/NOS3 (iNOS and eNOS) function, will also be affected by this depletion of BH4 because of excess ammonia! On top of all this, the depleted BH4 will make my body produce super oxide and, lucky me, I have several mutations in SOD3! Fortunately for me I don’t have a MTHFR A1298C mutation, that would complicate this even further.
- Lack of BH4 will cause mast cell degranulation and lead to higher histamine levels, with symptoms such as red hears and other hipersensitivity reactions. I have been suspecting high histamine for a while now as my white cell markers are a bit strange (some elevated, some decreased), anti-histaminics make me sleep the normal 8-9 hours, make me sleep almost through the night and if i wake up im able to fall asleep again. I used to have red hears all the time ever since a child up until my 18yo or so.
The Spasms are from estrogen dominance, take an AI if you don't believe me, they will go away, depending on the dose you require.i dont have any rx AI. what would be a natural safe alternative? I have a mutation related to estrogen dominance, can i use DIM or I3C?
Or chrysin.
“i dont have any rx AI. what would be a natural safe alternative? I have a mutation related to estrogen dominance, can i use DIM or I3C?”
I heard not to take DIM until you have gotten your methylation really working again or it may make the problem worse. I would avoid I3C. Maybe try zinc.
I have CBS, MTHFR, SOD3, NOS2. We are very similar. Let me know what you come up with and if anything ends up working well for you.