I mean why is there such a big difference in collapse times between patients, one month two months three months or even over half a year? WTF? Is there a proper theory to explain this, it doesn’t seem to have anything to do with dose
There are so many unanswered questions about this condition, and this is one of the bigger ones. The answer is “nobody knows”, which is why more research is needed.
If you want answers faster, you should support research into PFS.
You can also read up on the PFS Network’s literature review. Regarding a crash - this chapter seems like the most relevant: https://paper.pfsnetwork.org/#a_8220malignancy_switch8221_for_the_androgen_receptor
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