“Since finasteride inhibits T conversion into DHT, which is responsible for most androgen activity, it is plausible that prolonged finasteride use in predisposed individuals could simulate the effects of aging in young men. Since some of the effects of androgen inhibition can not be reversed once local androgen levels are re-established, it is temping to speculate that patients could still suffer from adverse sexual effects several months or even permanently after finasteride discontinuation because of aging effects caused prematurely by androgens deprivation, namely by artificially reduced DHT concentrations. Indeed, 2 of our patients were found to have low DHT levels in the cerebrospinal fluids long after finasteride discontinuation by Melcangi et al.” (Carla Di Loreto Francesco La Marra Giorgio Mazzon Emanuele Belgrano Carlo Trombetta Sabina Cauci. Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia, June 24, 2014 https://doi.org/10.1371/journal.pone.0100237
This a fucking nightmare