Don’t assume this is the best list. I tried to include a varied mix from different lines and categories of PFS research:
Studies showing biological abnormalities in PFS patients:
The “AR overexpression” pilot study:
C. D. Loreto, F. L. Marra, G. Mazzon, E. Belgrano, C. Trombetta, and S. Cauci, “Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia,” PLoS ONE , vol. 9, no. 6, p. e100237, Jun. 2014, doi: 10.1371/journal.pone.0100237.
The larger of the “neurosteroid deficiency” studies:
R. C. Melcangi et al. , “NEUROACTIVE STEROID LEVELS AND PSYCHIATRIC AND ANDROLOGICAL FEATURES IN POST-FINASTERIDE PATIENTS.,” The Journal of Steroid Biochemistry and Molecular Biology , doi: 10.1016/j.jsbmb.2017.04.003.
Methylation of 5-alpha reductase II gene pilot study:
R. C. Melcangi et al. , “Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study,” Endocrine Connections , vol. 8, no. 8, pp. 1118–1125, Aug. 2019, doi: 10.1530/EC-19-0199.
Abnormal fMRI findings, but authors associated this with depression. Also, I have heard there were significant differences in a few androgen-responsive genes, but these are listed in an appendix that I can’t access:
S. Basaria et al. , “Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss,” J Clin Endocrinol Metab , vol. 101, no. 12, pp. 4669–4680, Dec. 2016, doi: 10.1210/jc.2016-2726.
Literature describing symptoms of PFS:
M. S. Irwig, “Persistent sexual side effects of finasteride: could they be permanent?,” J Sex Med , vol. 9, no. 11, pp. 2927–2932, Nov. 2012, doi: 10.1111/j.1743-6109.2012.02846.x.
A. M. Traish, J. Hassani, A. T. Guay, M. Zitzmann, and M. L. Hansen, “Adverse Side Effects of 5α‐Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients,” The Journal of Sexual Medicine , vol. 8, no. 3, pp. 872–884, Mar. 2011, doi: 10.1111/j.1743-6109.2010.02157.x.
A literature review:
J. K. Than, K. Rodriguez, and M. Khera, “Post-finasteride Syndrome: A Review of Current Literature,” Curr Sex Health Rep , vol. 10, no. 3, pp. 152–157, Sep. 2018, doi: 10.1007/s11930-018-0163-4.
A review of the quality of finasteride’s clinical studies:
S. M. Belknap et al. , “Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-analysis,” JAMA Dermatol , Apr. 2015, doi: 10.1001/jamadermatol.2015.36.
A good beginner’s book on molecular biology if you don’t already have a basic background in biology and chemistry. Contains lots of descriptive cartoons, but it brushes upon the simplest concepts of many mo-bio topics:
Molecular Biology (made simple and fun), 4th edition
A good primer on molecular biology IMO, if you have a basic background in biology and chemistry:
Essential Cell Biology, 4th edition
I’ve never read a proper book on epigenetics, but @axolotl seems fond of this one. I think it provides a history of epigenetics, as well as scientific explanations :
The Epigenetics Revolution: (How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance,) 1st Edition