Does anyone know the mechanism of action by which beta sitosterol the active ingredient in saw palmetto inhibits 5 alpha reductase? Its molecular structure is similar to cholesterol so how does it inhibit 5 alpha reductase? Finasteride does it because it is a similar structure to testosterone and progesterone and cortisol so the 5AR molecules bind to it. Cholesterol is not similar in structure to testosterone so how does beta sitosterol inhibit 5AR?
Bump
there are many studies on pubmed which show it reduces DHT by 60% to 70% and reduces intracellular cholesterol. Also when given to male Goldfish reduces it’s testicle capacity to make testosterone (does not mention if this is reversible) Please search pubmed.I have given links here on the forum many times. But despite this all after been suffering for the last 5 years SP/BS is similar or maybe worse (yes it is many times more potent than Fin/DUT) than Dut. It does not make difference what you take to reduce 5AR. if it inhibits 5AR (fin, dut, sp, cottonseed oil which contains gysopyl which is 5AR inhibitor, Accai berry extract etc etc, you are doomed, the end of the story.
Medical community is well aware of gysopyl being 5AR inhibitor for decades. they know it shrinks penises and female reproductive organs of chinese people, in one study whole population of a town was infertile after consuming cottonseed oil. Long ago there was an attempt to make contraceptive drug from Cottonseed oil but side effects were so high that the researchers had to drop the idea But some how North American companies ditched the research and threw the position of Finasteride. Natural herbal companies followed them and threw Saw palmetto. So the rule of thumb is if you take 5AR inhibitors your dick will shrink along with many other health issues.
One more thing. Accutane and gysopyl give the same effects as Fin /SP being 5AR inhibitors but their molecular structure does not look like any hormones. Maybe during metabolism they become similar to some hormones.
Other studies have shown that Serenoa extract inhibits androgenic activity by competing with DHT for the androgen receptor, thereby affecting testosterone metabolism.13 The binding of two synthetic androgens, mibolerone and methyltrienolone, that are specific for androgen receptors at low concentrations (5nM), were inhibited by Serenoa extract (Permixon) in a competitive manner. Various plant steroids were tested for competitive binding to androgen receptors and found to be inactive.13,14 The inhibitory effect of Serenoa extract on DHT and testosterone binding was tested in tissue from 11 BPH patients. An average of 40%-42% reduction in receptor binding was observed for both hormones.15
legacy.uspharmacist.com/oldforma … icle_id=87
The bioactive substances in saw palmetto may actually interfere with the function of testosterone by blocking the androgenic and anabolic receptor sites of cells that testosterone needs to bind with to turn on cellular protein synthesis.
Saw Palmetto may actually interfere
with the function of testosterone.
Tests using tissue samples revealed that substances in saw palmetto actually reduced the tissue uptake of testosterone and dihydrotestosterone, which means saw palmetto bioactives blocked these anabolic hormones from entering cells, which is very anti-anabolic.