There is absolutely nothing interesting about me using the word “destroy” because that’s exactly what Minoxidil does.
“ Dissecting the underlying mechanisms, we found that minoxidil interfered with AR-peptide, AR-coregulator, and AR N/C-terminal interactions, as well as AR protein stability. Furthermore, a crystallographic analysis using the AR ligand-binding domain (LBD) revealed direct binding of minoxidil to the AR in a minoxidil-AR-LBD co-crystal model, and surface plasmon resonance assays demonstrated that minoxidil directly bound the AR with a Kd value of 2.6 μM. Minoxidil also suppressed AR-responsive reporter activity and decreased AR protein stability in human hair dermal papilla cells.”
It’s compromising the AR on a transcriptional and protein level. The effects that can have long term after applying generous amounts 2x a day for 6 months I don’t know. So far, it looks like people have had success with both desensitizing and resensitizing.