What happens to the finasteride-5ar2 complex after the inhibition? Perhaps its cumulation in the body is what’s causing the side effects. Can the body get rid of it? Has anybody studied it?
you mean Dihydro Finasteride instead of Dihydro Testosterone.
I put a study about two yound kids born in PAkistan with micro penises due to absence of 5AR enzymes. These siblings were treated with DHT which helped them grow their penises bigger. Please look at Fig 1. This is very informative reprot and we should go for high urinary tetrahydrocortisol (THF)/allotetrahydrocortisol (5 alpha-THF) ratio
as it says
In the younger sibling the diagnosis of 5 alpha-reductase deficiency was provisionally made at the early age of 3 days on the basis of high urinary tetrahydrocortisol (THF)/allotetrahydrocortisol (5 alpha-THF) ratio and this ratio increased with age confirming the diagnosis.
ncbi.nlm.nih.gov/pmc/articles/PMC1793798/
My question is why gene responsible for Androgen action was not turned off? why these young boys responded well to DHT application as opposed to us? I am asking for the sake of knowledge only. I don’t mean I win you lose the attitude here. Mew or Awor if you read this pleas respond.
Let’s stay on the topic please. It’s dihydrofinasteride binded to 5ar2 still, right, because otherwise it wouldn’t be inhibiting the enzyme. It has to stay blocking so testosterone can’t come in.
The reason why children respond to penis growth stimulants is that their penises are still growing. After puberty the penis won’t respond to DHT.