And what is not right is that most PFS docs are treating the condition by treating the symptoms, not the underlying cause.
Many of them seem to believe that PFS is a condition unique to each individual… while some of the side effects are in fact unique and blood tests do differ from person to person the fact remains that these appear only to be manifestations of the effects of PFS in different people.
Like treating my high cortisol… the high cortisol is most likely only caused by the immense stress that this condition has put in under and the fact that I am now living 2300 miles away from all my friends and family.
I have singled out and determined that every other hormone lvl in my body is relatively within range apart from my 3-Adiol-G and cortisol.
And low 3 adol G is a common denominator to almost everyone on this board apart from what? One person?
Mayo uses 3adiolg as a marker for peripheral tissue androgen metabolism by 5AR2, not AR insensitivity… which although I respect members with the opinion on this, AR insensitivity doesn’t make much sense… there are other reasons for muscle wastage and not many of us have this symptom. I am still 220 lbs 12% bodyfat… on the outside I look completely normal, on the inside I feel like my mind and emotions have been destroyed.
Just go to pubmed and look at all the studies linking 5AR2 to sexual behavior and defeminzation of the brains of developing male animals.
5AR2 metabolism is the problem here. We have DHT because of 5AR1 or perhaps deactivited DHT, but we are not getting the tissue metabolism that is required of 5AR2 for DHT to activate libido, sexual arousal, sleep (allopreg), and control brain fog.
Most of our proven evidence points to this. Why even focus on other ideas besides this and trying to figure what triggered it in us but not other men. Hyper sensitive immune systems, vunerable genetic dispositions, lack of DHT causes down regulation in 5AR2…
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We have evidence that points to 5AR2 issues.
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We only have theories about the other proposed causes, and dispite that some of these theories do fit, not all of them do in all cases and we have no actual evidence pointing to other causes.