Ways to raise allopregnanolone levels?

Therapeutic Efforts Pharmaceutical
#9

You don’t know this, maybe in healthy individuals who didn’t inhibit any important enzyme.

There are a mutliple enzymes involved in the production of allopregnanolone. From cholesterol, to pregnanolone, to progesterone, to 5α-dihydroprogesterone to allopregnanolone.

THC may augment one of these enzymes to induce allopregnanolone, but not if another is impaired.

The reason we had low allopregnanolone on the drug was due to 5-AR I inhibition. We need to establish if it’s still low after long-term discontinuation of the drug, and if so then why. Testing 5α-dihydroprogesterone should verify this.

#10

Danny you are completly right. Please can you add me.to skype so we can follow the same.path of investigation?

#11

Bump. I am taking low-dose SSRI however it is noticeably decreasing my testosterone and muscles however it definitely alleviate brain fog almost 100%. Also it alleviates the dark circles under my eyes and brings my face back to life sounds crazy but I promise you this is true I’ve experimented over the last five years. If we can find a way to raise Allo. Without the use of SSRI this will be a huge step. My respects to Danny and all he has done for us

1 Like
#13

Interesting. I’m now at a catch 22, I’m having real serious signs of liver trouble from trying to treat this PFS brain fog. If it gets any worse I will have to go cold turkey off any and all medication. Then I will be back with the mental sides. It will come down to exercise meditation and natural approaches. However I have given myself 6 years or so without suffering from brain fog by taking Zoloft off and on. Of course once I stop Zoloft brain fog continues. But I am not willing to kill my liver with antidepressants, then I’d have PFS and liver disease, not fun. Maybe time to try and drop the meds.

#14

Picture of jawline of 29 year old man - prime years of my life. No wonder I consider suicide every day. I took 9 pills 6 fucking years ago when is it gonna end

CD27BB7A-2430-4F02-88A7-F7A35DFED099.jpeg2320×3088 1.43 MB

#15

Sounds like you need an attitude adjustment dweeb, my girlfriend’s probably got more testosterone than you. Have you seen yourself in the mirror? You look like a dork, I want punch you right now.

(I’m preparing you for the real world)

2 Likes
#16

Ok well thanks for that. Yea it’s just a downswing but I’ll come out of it. If u just going to insult a PFS sufferer good riddance to you

#17

America is full of obese people. Are you saying they’re stronger than you to put up with it? If you’re suicidal because you’re not in top shape that is simply pathetic. You get to live this way temporarily as a lesson and you’ll be back to your more or less handsome face and able body in no time. Use this as an opportunity to see what others go through. That goes for everyone. That’s what I’m trying to do.

#18

I’m not sure if you’re quite aware ignite of what has happened to scared. If you look at photographs of him prior to pfs which have been posted on this site then you will see that he, like others, have experienced significant changes to their faces. Scared had a strong jaw line which has appeared to have been decimated by this drug. I’m not sure if this is easily remedied. Scared is brave by posting these photos and has been through a lot. Some guys with pfs can’t shift additional weight also. It’s a shame that this community can sometimes attack itself like it does when we show our vulnerabilities. It’s a bit douche like tbh. Too many belly rumblers on here, as in open your mouth and let your belly rumble.

2 Likes
#19

That’s right I don’t think its helpful to abuse fellow pfs sufferers especially as we are all a bit vulnerable with our mental health. We really need to stick together and support each other. Hopefully the update to the forum will be coming through soon, so that posts are easier to follow.

#20

We shouldn’t have those vulnerabilities

#21

I didn’t notice any different. I might have noticed more from beer. I bought pricey sorghum based gluten-free beer to prevent estrogen.

#22

I heard DHEA could help.

#24

Are there any other drugs that increase allopregnanolone levels that are not listed here ?

#25

etifoxine

#26

Do we have a picture to compare?

#27

I tried 5dhp of IdealLabs, definetly worked.

#28

In what way

#29

What is your SSRI protocol? I also want to try it low-dose.

#30

Wow this is the most striking before/after face/jaw shrinkage pics I’ve found here. Compared to the pics in this link progress - General Discussion - propeciahelp.com

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This picture sequence should be included with every Propecia prescription as a warning.
Anyone know if @scaredoutofmymind is still around? Looks like he posted some improvements a while back but not specifically about this.