Yes, the study on CAG repeats is interesting. But it doesn’t explain why also people with short and medium repeats get PFS. Probably those with longer CA-repeats are the ones who get symptoms after just a few pills of Finasteride and yes, I think it turns them from hyperandrogenic to hyperandrogenic. But what is the mechanism behind?
As far as I know CAG repeats are hard-coded on the DNA and either you are born with it or not. Epigenetic changes or more like a cap that sits on top or like a locker that could be removed. So I think it is not possible to gain CAG repeats.
As CAG repeats are associated with hair loss and people with hair loss are more likely to use finasteride there may be a selection bias that CAG repeats are overrepresented among PFS patients when it actually not necessarily would be the case.
Still I think the there may be something to the AR although it does not explain changes in neurosteroids and 5AR2 methylation among many patients.
Don’t know if there are any studies on CAG and prostate cancer. Would make sense. It would also mean bold guys may have more or more aggressive prostate cancer.