Like it says in the title, i just found what I believe is a very interesting article which compared PFS users with asymptomatic fin users and it claims the following:
"Serum DHT levels, testosterone to DHT ratios, and circulating markers of tissue testosterone metabolism through the SRD5A pathway, 5-androstane-3, 17-diol-glucuronide, and 5-androstane-3, 3-diol-glucuronide levels, and the ratio of ADT-G to ETIO-G, were similar among groups, providing no evidence of persistent inhibition of peripheral SRD5A activity by prior finasteride use. The nucleotide sequences of the AR, SRD5A1, and SRD5A2 genes did not reveal any explanatory variation in the coding regions or splice sites or in CAG repeat length in men with persistent symptoms.
Furthermore, the peripheral markers of androgen action (hair growth, acne, and sebum production, hematocrit, PSA levels, lean body mass, and the expression levels of nuclear AR and -catenin proteins, and other androgen-regulated mRNA transcripts in the skin) did not differ among groups.
Although we did not have a control group of profoundly hypogonadal men such as those receiving androgen deprivation therapy, the analyses of differential gene expression did not reveal patterns of alterations in gene expression that have been reported previously after androgen deprivation or androgen supplementation in preclinical and clinical models (31, 32).
Thus, persistent sexual symptoms in men who had previously used finasteride, are unlikely to be due to androgen deficiency, variations in the coding regions of the AR, SRD5A1, or SRD5A2 genes,
persistent peripheral inhibition of SRD5A1 and SRD5A2 genes, or to persistent off-target inhibitory effects of finasteride on peripheral androgen action"
"The clinical implications of these findings are that symptomatic finasteride users are unlikely to benefit from treatment with testosterone, DHT, or any other androgen, because these patients do not have evidence of androgen deficiency, persistent SRD5A inhibition, or androgen insensitivity"
Here is the link to article, hope someone can understand it better than me: