Update scary symptoms HELP

General Discussion
#22

Hey there, Northern_Star!

I read your comment and your refer that we already hava a “Decent basic Idea of what is wrong with us”.

I’m kind of new to this forum and, althought, I’ve read through a lot of topics, I couldn’t learn, quite well, where we are in the path to understanding this syndrome right now…

I know there are three major studies funded by the PFS Foundation (Brigham, Baylor and Milano), but I couldn’t translate to a non-scientific vocabulary what has already been revealed by the researchers.

I have an appointment with one of the best andrologists in my town next friday and I would like to give him realiable info about PFS and also provide him with sufficient material to, maybe, seek some different treatment approach.

I’d be forever glad if you could help me doing this and I also claim other community members to contribute as well!

#23

Hey @Omega123, welcome to the forum! Please let us know the results of your appointment. In the meantime, would you mind taking the survey? It’s the most important thing any of us can do in our quest for a treatment, the gathering of the necessary information is vital. It won’t take too much of your time but it will save your progress if you wish to complete it in stages. :+1:

1 Like
#24

Sure thing!

#25

Appreciate it brother

1 Like
#26

Dear Omega123,

Welcome to the forum! It may not always be apparent from the normal daily discussion on this forum, but, yes, the admins of the forum have a pretty clear idea what the basis of our problem is and what we have to do to advance our cause. We, the staff, and many members here support them in this quest. Awor has detailed the underlying idea a decade ago in a paper: http://www.protocol-online.org/forums/uploads/monthly_08_2010/msg-19273-027408800%201282061244.ipb. In short, it goes like this (quote from the paper):

  1. AR overexpression (hypersensitivity) as a result of decreased androgen (DHT) availability
  2. Silencing of AR signal through negative autoregulation as a result of overexpressed AR signal
  3. Lacking induction of the 3α-HSD enzyme as a result of a silenced AR signal
  4. Epigenetic changes in homeostasis resulting in permanently altered levels of gene expression

Since 2009, studies have confirmed androgen receptor overexpression (Di Loreto et al.), dysregulation of neurosteroids possibly due to the lacking induction of the 3α-HSD enzyme (Caruso et al.) and we have some hints from the recent Melcangi study that something is going on on the epigenetic level. Unfortunately, a critical piece of research investigating gene expression is long overdue, limiting our options going forward. But we are hopeful that this research will be published in the near future and are already working on how to initiate the next line of research. You can help us to that by contributing to the projects outlined here: (17) I took a single pill of finasteride 4 months ago and I’m going through hell

With regard to your andrologist, the relevant literature is on the website of the Post-Finasteride Syndrome Foundation. In addition to the more specific studies mentioned above, there are two literature reviews that may give your andrologist a good overview:

Traish, A.M. Curr Sex Health Rep (2018), The post-finasteride syndrome: clinical manifestation of drug-induced epigenetics due to endocrine disruption
Than, J. K., Rodriguez, K., & Khera, M. (2018). Post-finasteride Syndrome: A Review of Current Literature

Unfortunately, there is currently no known effective and safe treatment for this condition. So, I would not get expectations too high irregardless of the standing of the andrologist.

3 Likes
#27

Thank you very much, brother! You did me a huuuge favor! Let us remain strong as que wait for the researches to move forward! God bless you!

1 Like
#28

This is my first time reading this study thank you for posting and thank you to @Mew and @awor for the hard work you guys do I really appreciate it

3 Likes
#29

Yeah, what we know and what we suspect about this condition is a bit scattered all over the forum and not summarized on a single page somewhere. It’s a problem that we are aware of. This will change in due time.

@Axolotl, who has taken over as Admin and who has worked very hard to upgrade the forum and create the survey, is currently working on a paper that will basically be a successor to Awor’s paper linked above. Together with emerging research and our community projects, this will hopefully be a launching pad for future research. Once we have reached these milestones, the intention is there to make a more comprehensive statement of where we are, where we want to go and what we need everyone to do with regard to future research.

We are not quite there yet. That’s why there is not something big to be announced every week or every month. But that does not mean that things are not moving ahead. So, please be patient, check in here every now and then, and please support our projects. It is very important!

3 Likes
#31

I know mods are working hard but im curious:

how far is he into the paper? like what’s a time limit until publishing?