Trenbolone many times more anabolic|androgenic than test

Therapeutic Efforts Pharmaceutical
#1

Tren has a higher androgenic raiting that test.
Tren does not need to be 5a reduced to have potent androgenic effects.
Tren can not be converted to estrogen.
There are anecdotal reports that tren increases / decreases libido. Obviously running it without test / hcg would kill your libido due to no estrogen.

I think this is surely worth a try. You just need to ensure you get a clean source and take a small dose. 3 mgs or so per day.

I now have more viseral fat (love handles) after stopping fin.
My teeth started hurting a few months after quitting fin.
I know my body can be horny as I got libido back for a short period on arimidex.

Most of the side effects reported on the net are from people taking 30 + mg per day. That is almost like taking 100mg test eveyday, it is expected you would get servere side effects on this dose.

Abstract

Selective androgen receptor modulators (SARMs) now under development can protect against muscle and bone loss without causing prostate growth or polycythemia. 17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone), a potent testosterone analog, may have SARM-like actions because, unlike testosterone, trenbolone does not undergo tissue-specific 5α-reduction to form more potent androgens. We tested the hypothesis that trenbolone-enanthate (TREN) might prevent orchiectomy-induced losses in muscle and bone and visceral fat accumulation without increasing prostate mass or resulting in adverse hemoglobin elevations. Male F344 rats aged 3 mo underwent orchiectomy or remained intact and were administered graded doses of TREN, supraphysiological testosterone-enanthate, or vehicle for 29 days. In both intact and orchiectomized animals, all TREN doses and supraphysiological testosterone-enanthate augmented androgen-sensitive levator ani/bulbocavernosus muscle mass by 35-40% above shams (P ≤ 0.001) and produced a dose-dependent partial protection against orchiectomy-induced total and trabecular bone mineral density losses (P < 0.05) and visceral fat accumulation (P < 0.05). The lowest doses of TREN successfully maintained prostate mass and hemoglobin concentrations at sham levels in both intact and orchiectomized animals, whereas supraphysiological testosterone-enanthate and high-dose TREN elevated prostate mass by 84 and 68%, respectively (P < 0.01). In summary, low-dose administration of the non-5α-reducible androgen TREN maintains prostate mass and hemoglobin concentrations near the level of shams while producing potent myotrophic actions in skeletal muscle and partial protection against orchiectomy-induced bone loss and visceral fat accumulation. Our findings indicate that TREN has advantages over supraphysiological testosterone and supports the need for future preclinical studies examining the viability of TREN as an option for androgen replacement therapy.

Abstract

Recently, the development of selective androgen receptor modulators (SARMs) has been suggested as a means of combating the deleterious catabolic effects of hypogonadism, especially in skeletal muscle and bone, without inducing the undesirable androgenic effects (e.g., prostate enlargement and polycythemia) associated with testosterone administration. 17beta-Hydroxyestra-4,9,11-trien-3-one (trenbolone; 17beta-TBOH), a synthetic analog of testosterone, may be capable of inducing SARM-like effects as it binds to androgen receptors (ARs) with approximately three times the affinity of testosterone and has been shown to augment skeletal muscle mass and bone growth and reduce adiposity in a variety of mammalian species. In addition to its direct actions through ARs, 17beta-TBOH may also exert anabolic effects by altering the action of endogenous growth factors or inhibiting the action of glucocorticoids. Compared to testosterone, 17beta-TBOH appears to induce less growth in androgen-sensitive organs which highly express the 5alpha reductase enzyme (e.g., prostate tissue and accessory sex organs). The reduced androgenic effects result from the fact that 17beta-TBOH is metabolized to less potent androgens in vivo; while testosterone undergoes tissue-specific biotransformation to more potent steroids, dihydrotestosterone and 17beta-estradiol, via the 5alpha-reductase and aromatase enzymes, respectively. Thus the metabolism of 17beta-TBOH provides a basis for future research evaluating its safety and efficacy as a means of combating muscle and bone wasting conditions, obesity, and/or androgen insensitivity syndromes in humans, similar to that of other SARMs which are currently in development.

When used in connection with animal production the term “anabolic agents” covers a wide range. Ther steroidal male and female sex hormones are included in this list, as are the nonsteroidal estrogens. For the clinician and for the endocrinologist, anabolics are only steroids chemically related to testosterone and 19-nortestosterone. Estrogens, though possessing anabolic properties, too, do not belong to this class. This paper will deal with anabolic agents in in the stricter sense of which mainly trenbolone acetate combined with hexestrol has been recommended for bull and heifer fattening. To consider possible consumer injury from ingestion of meat from anabolic agent treated animals, it is necessary to know the pharmacological properties of the agents, the doses producing certain effects or might produce, and the levels of residues in the meat. Trenbolone acetate will be compared with the following anabolic agents: methenolone acetate, methandrostenolone, nandrone, androstanazole, and 19-nortestosterone. The activity spectrum of trenbolone acetate is similar to that of 19-nortestosterone or those anabolics that are derived from 19-nortestosterone. The compound has about three times stronger androgenic effect than testosterone propionate. Its index of dissociation between anabolic/androgenic activity is 2–3. This index is 3–10 for the other anabolic agents. As regards the virilizing potency, trenbolone acetate is also on the top of the list. It seems that androgenicity and degree of virilization run paralle. The antigonadotropic activity (inhibition of ovulation and testicular growth) of trenbolone acetate exceeds that of testosterone propionate by the factor 3. The compound is not estrogenic and seemingly not or only weakly progestationally active. In principle, the androgenic activity (symptoms of virilization) as well as the antigonadotropic effect (disturbances of the menstrual cycle in women, inhibition of spermiogenesis in men) of trenbolone acetate might be noted. This risk, however, can be excluded by mere calculation. In rats, 0.1 mg/kg trenbolone acetate have an antigonadotropic effect. This corresponds to a daily dose of 5–7 mg in humans. By the same extrapolation, a daily human dose of 100 mg can be calculated for androgenic activity. Such factors of conversion are, of course, not precise because rats are much less sensitive to androgens and anabolics than humans. Thus, testosterone propionate is active only in daily doses of 10–20 mg. If in humans trenbolone acetate also has three times the activity of testosterone propionate, effects in man had to be counted with not less than a daily intake of 3–5 mg trenbolone acetate. The dose which is recommended for livestock fattening is 300 mg. IT can, therefore, be excluded almost with certainty that the meat would contain such large amounts of hormone residues.

#2

Trust me when I say this won’t fix you.

#3

Reason?

#4

low estrogen cause low libido? really?

#5

really.

#6

i knew high estrogens cause low libido.

#7

Now you know it’s a matter of balance.

#8

Balance is very very important. Estrogen can bind to the androgen receptor and cause no action.

I fixed my self briefly on arimidex. Libido came back strong. My free testosterone to estrogen ratio is way out of wack.

It is critical these 2 are in balance. You need both hormones in the right proportions for libido. This is why arimidex is such a hard drug to use. One min your too high the next min your too low.

I am hoping that by taking TEST without HCG I can shut of the estrogen my testicles are producing and lower total estrogens, increase TEST, decrease SHBG which will increase free test and lower estrogen. Do not know if this will work.

I will inject 32.5mg every 3 days. Maybe less.

#9

Its an incredibly potent anabolic steroid. It will shrink your testicles and ruin your libido, from what I know about it this is because it raises prolactin.

It’s given to cattle a few weeks before slaughter because it does have an incredible effect on increasing mucle mass. But it has terrible side effects of its own, nothing compared to finasteride though.

#10

You can have libido without testicles. As long as you have testosterone and enough estrogen. At low doses the prolatcin agonizing qualities would be very low. Ie 30 mg per week.

Yes I do not think you could take it for ever but at a very low dose for a few weeks it could help raise the androgen balance.

Some people report super high libido on trenbolone other get low libido.

#11

I am on Trenbolone Acetate now. A little unsure of the quality of the gear. I could have gotten better stuff but that had a longer lasting ester. Was a bit worried about that. Will take it for a week or so and see what happens. I am adding a small amount of test.

#12

metribolone aka methyltrienolone has the highest affinity for the androgen receptor out of any androgen. might be worth trying that out if you can get some

#13

I don;t think you know what your talking about. It is an oral and theirfore toxic version of Trenbolone.

Methyltrienolone

Methyltrienolone (MT) is a very potent, reasonably toxic, non-aromatizing steroid. Ok. Lets go over those three points again. First of all, MT is potent. It binds so strongly to the AR (androgen receptor) that it is often used in studies on other androgens to measure how strongly they bind. In other words, this stuff binds onto the AR receptor so strongly that it is pretty much the benchmark for that quality. If youve read my profile on Trenbolone Acetate (TA), youll note that I said TA is the most potent injectable weapon in our arsenal with regards to ability to bind to the Androgen receptor. Thats still true, because this particular compound is not in our arsenal, and its not injectable… its simply the oral version of TA (i.e. it is Trenbolone which has undergone modification to become orally active, via the addition of a 17-alph-methyl group). So why is it important that this stuff binds so tightly to the AR? Well, Androgen Receptors are found in both fat cells as well as muscle cells(8); they act on the AR in muscle cells to promote growth, and in the fat cells to affect fat burning.(9)(6) The stronger the androgen binds to the A.R, the higher the lipolytic (fat burning) effect on adipose (fat)tissue(9)(5). Unfortunately, that strong binding doesnt also automatically mean that it will elicit the strongest possible anabolic response, nor that the weakest bind will elicit a weak anabolic response. Anadrol (oxymetholone) has the weakest bind to the AR possible (too low to be measured), and it produces a profound anabolic response, for example. Dianabol is simarly low, and produces a very good anabolic response. ARs are found in both muscle tissue as well as adipose tissue. When a muscles AR is stimulated, it can induce hypertrophy. When an adipose tissues AR is stimulated, through various related mechanisms, fat is lost. This is a gross oversimplification. Whatever. All we need to know is that when you have a steroid that binds to the AR, it builds muscle and burns fat. And a steroid that binds very tightly to the AR will stimulate a lot of muscle synthesis and burn a lot of fat. A good example of this is Trenbolone. And since I mentioned Trenbolone, its worth further mentioning that MT is basically a 17aa (oral) version of (injectable) Trenbolone. AR binding and AR stimulation is not the only mechanism which stimulates anabolism, however. It is important to note that dbol has a very low AR binding ability and A50 has an AR binding ability which is too low to even measure! Both are very potent oral steroids, though. So while its important, AR binding/stimulation is not the end all & be all of anabolism, although it is an important part. Dont be fooled by the anabolic/androgenic ratio of this (or any steroid), either. The anabolic/androgenic ratio of MT would suggest that it produces 120(+)x the anabolic and 60(+)x androgenic effect of Testosterone (which has a score of 100 and 100 respectively). If one were able to get a bottle of this stuff, I believe it would be best used as part of a cutting cycle, stacked with some injectables (testosterone, etc… ), but certainly no other orals. Its just too toxic. Negma (the French company who brought Parabolan to the market, and then discontinued it) never pushed MT to gain approval as a commercially released item, since their original studies showed it to be highly toxic. Methyltrienolone is, of course, a 19Nor compound (as is Trenbolone)…Thus, it will effect your sexual drive and performance in a similar way to both Tren and Nandrolone, meaning that Temporary Impotence and/or a lack of libido is highly possible (aka Tren-Dick or Deca Dick)(10). Another problem with MT is that it is a progestin, and binds shockingly well to the progesterone receptor also (PgR) (3). As we know, progestins amplify estrogenic effects of Aromatizing drugs. Although MT doesnt aromatize, you will still need to worry about its ability to cause side-effects by amplifying the estrogenic issues caused by the other compounds you may be taking. How toxic is this stuff? Well, it was never commercially marketed for use in humans, and has been relegated to Steroid-Purgatory, to be used only in studies. Id probably rate it on around the same level as taking very high doses of halotestin or methyltestosterone. And Id probably recommend that people keep doses of this product very low, much lower than recommended doses typical of the other 2 compounds I just mentioned (i.e. 500-750mcgs/day, for not much longer than 3-4 weeks). I have had the good fortune to discuss this product with the owner of an Underground Lab, and he had given out several samples of this stuff to athletes he knew, and they all kept records and got regular bloodwork done. People who were in the 2mg/day range developed highly elevated liver enzymes and Jaundice (yellowing of the eyes and skin). They all recovered, and through trial and error, a 500-750mcg dose was found to be (*relatively) safe, and (*roughly) as effective as 150-225mgs of Trenbolone Acetate. For women, a possible side effect of MT is Virilization (development of male sexual characteristics), which is profound with this stuff (11), so it is entirely off limits for women to use. You may want to take milk thistle with this compound, should you decide to try it, as well as (320mgs/day), ALA (500mgs per meal) and try some Pygeum Africanum (Permixon, the liposterolic extract of Serenoa)… stuff will all protect either your prostate or liver… in one study, it inhibited competitively the binding of Methyltrienolone to the cytosolic receptor of the rat prostate. Youll still need to get blood work done, avoid other orals (this includes drinking, or anything else which could tax your liver), and monitor your health closely. This isnt a drug for novices, clearly, and is probably only useful for pre-contest bodybuilders. Ive only seen MT available from one Underground Lab, and it came in a 50ml bottle, which was 1mg/ml, and was priced at $100. This translates to roughly 100 doses, at a reasonable cost of fifty-cents per dose. And since you would never want to run this particular drug for longer than 3-4 weeks at a time (maybe it would have use in the last few weeks before a bodybuilding competition, but not much else), youll get to use one bottle in 4 different cycles. That makes it no less dangerous, just reasonably cheap.

#14

Well. As soon as I injected the Trenbolone, I had this feeling in my back. A pain on the right hand side. Perhaps my liver. Anyway, apart from this did not notice too much. Had better morning woods. I would keep injecting it but the pain in my back is concerning. I dont want liver disease.

Dono whats next. I have some equopse. That converts to E2 at a slower rate than test. May try this with proviron for DHT.

#15

I think that you would feel liver pain in your front side not back…slightly on the right side

#16

Well I am not sure what pain it is. But steroids users get what is called back pumps when they take pro hormones and other steroids. Since I stopped it it has gone away.

#17

Please don’t touch Tren! Google something called Tren dick. It can destroy your libido even worse. I know many people where this has happened.