Took an antidepressant years after finssteride

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#1

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Sexual
[ x] Loss of Libido / Sex Drive
[X ] Erectile Dysfunction
[ ] Complete Impotence
[ x] Loss of Morning Erections
[ x] Loss of Spontaneous Erections
[ c] Loss of Nocturnal Erections
[ ] Watery Ejaculate
[ ] Reduced Ejaculate
[ ] Inability or Difficulty to Ejaculate / Orgasm
[ ] Reduced Sperm Count / Motility

Mental
[ ] Emotional Blunting / Emotionally Flat
[ ] Difficulty Focusing / Concentrating
[ ] Confusion
[ ] Memory Loss / Forgetfulness
[ ] Stumbling over Words / Losing Train of Thought
[ ] Slurring of Speech
[ ] Lack of Motivation / Feeling Passive / Complacency
[ ] Extreme Anxiety / Panic Attacks
[ ] Severe Depression / Melancholy
[ ] Suicidal Thoughts

Physical
[ ] Penile Tissue Changes (narrowing, shrinkage, wrinkled)
[ ] Penis curvature / rotation on axis
[ ] Testicular Pain
[ ] Testicular Shrinkage / Loss of Fullness
[ ] Genital numbness / sensitivity decrease
[ ] Weight Gain
[ ] Gynecomastia (male breasts)
[ ] Muscle Wastage
[ ] Muscle Weakness
[ ] Joint Pain
[ ] Dry / Dark Circles under eyes

Misc
[X ] Prostate pain
[ ] Persistent Fatigue / Exhaustion
[ ] Stomach Pains / Digestion Problems
[X ] Constipation / “Poo Pellets”
[ ] Vision - Acuity Decrease / Blurriness
[ x] Tinnitus (ringing or high pitched sound in ears)
[ ] Hearing loss
[ ] Increased hair loss
[ ] Frequent urination
[ ] Lowered body temperature

[ ] Other (please explain)

What (if any) treatments have you undertaken to recover from your side effects since discontinuation of the drug? None

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Tell us your story, in your own words, about your usage and side effects experienced while on/off the drug.

Years ago I had pfs for a while after stopping fin
Ot wasn’t that bad un that I ecovesd within a year ir twi naturally

Following a period of stress I took an antidepressant and have since had a bad crash and lost muscle as well as libido. It’s much worse than the pfs crash

I didn’t know about “pssd” or whatever its called. I k ow they had potential long term sexual sides but I have been surprised to see the PSSD full spectrum of sides on that reddit and social.media. pssd wasn’t a thing when I had pfs, at least that I noticed.

Reading here and elsewhere its seems that having had pfs before made me more vulnerable.

Idk what to do, my t levels are in range and urologist didn’t help. I feel worse after ejaculations etc. I also can’t get drunk. I never knew this was a symptom

Can simeome tell me, are pfs and pssd the same thing?

Why can’t I react to substances anymore and what has this to do with AR overexpression?

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  1. Name of the therapy/substance:
    • Dosage:
    • How often you took it:
  2. Status
    • Still using [ ]
    • Stopped with no lasting change to initial symptoms [ ]
    • Stopped with persistent change to symptoms [ ]
  3. Duration of use: Days [ ] Months [ ] Years [ ]
  4. Response when you started:
    • Greatly improved [ ]
    • Slightly improved [ ]
    • Stayed the same [ ]
    • Slightly worsened [ ]
    • Greatly worsened [ ]
  5. Current response (if you’re still using the therapy/substance) OR Response in the time before you stopped the treatment
    • Greatly improved [ ]
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#2

I had mildish pfs that went away after a year or so about ten years ago.

In that time I remember people on here taking remeron aka mirtazipine for sleep. Now I read that drug alone cam crash people like pfs.

Can someone explain why substances no longer exert any effect? How does this tie in with the AR overexpression theory? It seems like brain damage.

I can also bo longer get a rush from music. It feels like dopamine has been turned off. I never had these symptoms with pfs, I think I briefly had the loss of feeling from music but it went away and I attributed it then to depression.

#3

Could you fill in some extra info, in the first post, the name of the antidepressant, etc please?

In answer to your question, we see significant overlap with PSSD patients. Until we know more, it’s impossible to say the conditions are the same but you might take a “walks like a duck, quacks like a duck” attitude to it.

I remember when I first had pfs and lost enjoyment in a number of things, including music. With time, this has come back to me.

1 Like
#4

They share the estrogen receptor dysfunction

#5

Thanks for your reply.

I too lost enjoyment in music when I had pfs but it wasn’t that long and it didn’t feel.like something had been switched off. Now I understand why people say nysic does nothing, the endorphin or dopamine rush has gone.

Same with androgenic action it feels totally switched off I don’t get erections at all nor.muscle pump

I’ve read the last few weeks on here and reddit
I understand the melcangi research isn’t rated by this group and I agree going along with the analysis.

I took mirtazipine and 25mg seroquel.

I feel.i had a double crash as I had a mini crash the year before when penile skin darkened. Then a huge crash a year later after stopping and starting it for sleep.

I have bad tinnitus and food intolerance and am.almost incapacitated. Pfs hit me quite herd initially and I fully recovered but this is off the scale.

3 Likes
#6

Where are u from @Kames…

#7

Also been reading latealy that this Melcangi guy is a clown. What do wiser people say about this and people closer to the research? And are we content about current rate of all of the researches?

#8

Yeah I’ve been there before. I can actually gauge where I am by those 2 things. Erectile response to visualized sexual thoughts with mentally simulated sensations and my musical enjoyment. The 2 systems through some component in the brain that is able to simulate sensations by imagining them and visualizing them gets screwed up in this bubble of conditions. I don’t know what this is though but the common factor with me worsening is this will always get worse and the closer I am to a crash the worse it will be. If I am crashed I won’t be able to mentally visualize anything at all simulate sensations. I also won’t be able to intellectually access myself either using these same mechanisms. Nothing would be fire in response to anything at all and my mind would just be black. Nothing there, thoughts about anything turn into a little flicker and nothing sets off.

When I was severe all of these things were completely absent altogether and I felt like I was gonna die 24/7. There is something connecting the androgen receptor systems to the whole dopamine excitory systems that appears to break and when it does both of these systems no longer function and the body can’t barely function anymore when it does too leading to a lot of strange downstream problem. To me this seems like an overall receptor dysfunction where it doesn’t matter what it is, the brain in some almost emergency like response gone wrong shuts down everything and doesn’t turn it back on. There have been times where I had individual symptom windows with overall an overall still crashed state. A perfect example of this is when I had a full sexual window with Tongcat and actually had issues “keeping it down” but literally nothing else would work. Full sexual responses to what I was attracted to with literally nothing else, not even the pleasure response. It was the most alien thing I had ever experienced and I don’t think I want to feel anything like it ever again. So like everything was still there but it wasn’t working anymore and then one thing was able to turn one thing back on but nothing else. Of course when I stopped so did it and it otherwise made me feel like ass further so I stopped using it after that week.

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#9

Is this now like a sort of pssd forum too?

I think from reading that I “kindled” these drugs and that may be why I crashed so hard.

The contrast between life before and after is immense. I had had pfs but all mental and pretty much most sexual sides had gone. I didn’t really know what anhedonia was now i feel it intensely

Can this be all AR related, or are we also looking at neurological damage.

1 Like
#10

There is probably a lot of cross over, my situation was saw palmetto induced and supplements I was taking at the time train wreck. From my experiences and what’s going on now with things it feels like with this condition so much goes wrong that you can’t pin it to a single thing. I personally based on how I felt and what was going on at first had neurological damage, hormonal insensitivity, neurotransmitter insensitivity, immune dysfunction, something horrific going on in my guts producing neurotoxins perpetuating it, poorly controlled infections gone wild, and probably a lot of induced deficiencies. All in all I’m surprised I’m not dead. That’s why we have no answers to any of it besides a million clues. In a nutshell I got better I feel by immune strengthening, herbal antibiotic using, calming down the bad things going on in my immune system at the same time, and somehow restoring the functionality of my neurotransmitter and hormone systems but like I said I can’t tell if it was desensitization or my body stopped producing things altogether. My final push here seems to be with suppressing some kind of ongoing neurotoxin producing infection in my guts. I’m going to try using psyllium husk next and see where that goes.