Toll-like receptor 2 plays a critical role in pathogenesis of acne vulgaris

General Discussion
#1

Just throwing down a few notes here.


All trans retinoic acids such as isotretinoin (Accutane) have been shown to generate long-term remission by inducing sebocyte apoptosis, decreasing the expression of TLR2 and pro-inflammatory cytokines in monocytes and suppressing MMP production.

What im currently looking at as far as trying to reverse this possibility.

COMMON OVER‑THE‑COUNTER MEDS SHOW SIGNS OF BOOSTING ANTI‑CANCER IMMUNITY

Histamine receptor 2 is required to suppress innate immune responses

Cytokine secretion following Toll-like receptor (TLR)-2, TLR-4, TLR-5, or
TLR-9 stimulation in the presence or absence of histamine or famotidine (H2R antagonist) was quantified.

Deliberate manipulation of H2R signaling may suppress excessive TLR
responses to bacteria

RESULTS:
Histamine effectively suppressed TLR-induced cytokine secretion
Famotidine reversed this suppressive effect

im being selective with the cliff notes, just looking at possibilities.

#2

Adding to this,

Toll-like receptor 2 plays a critical role in pathogenesis of acne vulgaris

Cutting Edge: All-trans Retinoic Acid Down-Regulates
TLR2 Expression and Function

Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients.

“TLR-2 modulation may be involved in the durable therapeutic response to isotretinoin. This study demonstrates that isotretinoin exerts immunomodulatory effects in patients and sheds light on a potential mechanism for its long-term effects on acne.”

Severe acne treated with Isotretinoin is associated with dysbiosis and its consequences

Isotretinoin is associated with dysbiosis (perhaps malabsorption) and signs of dysimmunity.

Isotretinoin is known to impair stem cells renewal and TLR2 expression in the mucosa of the
small gut

In addition, isotretinoin normalizes [58,59] exaggerated TLR-2-
mediated responses in acne patients [60,61]. Since TLR2 plays many
positive physiological roles, deleterious consequences of its blockade
are expected

Symptoms develop more than 20 years after the intake of the medication taken at usual range and duration.

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