I noticed this mentioned in one of cumkwakka’s post and thought that it deserved some investigation.
Tianeptine is an SSRE (selective serotonin reuptake enhancer) effectively the opposite of an SSRI. As we know SSRIs cause many of the same symptoms we are experiencing so it would be interesting to know what effect an SSRE would have, if any, on our symptoms. It is worth noting that it has shown to be effective at treating men with ED.
en.wikipedia.org/wiki/Tianeptine
Tianeptine (INN) (Stablon, Coaxil, Tatinol) is a selective serotonin reuptake enhancer (SSRE) drug used for treating major depressive episodes (mild, moderate, or severe). Unlike conventional tricyclic antidepressants, tianeptine enhances the reuptake of serotonin instead of inhibiting it, opposite to the action of SSRIs. Moreover, it enhances the extracellular concentration of dopamine in the nucleus accumbens[2] and modulates the D2 and D3 dopamine receptors.[3] There is also action on the NMDA and AMPA receptors.