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Can high nor-ep cause chronic ED ? If so , how? What can be done?
High norepinephrine levels (or relatively high norepinephrine levels compared to the other neurotransmitters) can cause erectile dysfunction (chronic or otherwise).
Norepinephrine is the primary signal in the brain for stress. It is a excitatory neurotransmitter. It keeps a person awake. It can help improve attention. It causes an increase in ACTH production, which then drives adrenal hormone production. A spike of norepinephrine triggers orgasm/ejaculation in men. Norepinephrine is the primary chemical messenger of the sympathetic nervous system (the system that responds to fight-or-flight, stressful situations).
When a person has chronically high norepinephrine, it can cause anxiety or irritability. It can eventually cause adrenal depletion, fatigue, or frank adrenal insufficiency. This can then lead to erectile dysfunction, loss of libido, sexual dysfunction.
To keep norepinephrine levels high, the brain may have to lower the production of dopamine, which can lead to loss of libido and erectile dysfunction. Lowered dopamine production, itself, can reduce testosterone production (though high norepinephrine can raise it - causing a wash if the balance is maintained). Lower testosterone can lead to erectile dysfunction. Lowered testosterone production can lead to insulin resistance and further metabolic cascades that can cause erectilve dysfunction and lack of libido.
Chronically high norepinephrine production in the absence of other neurotransmitter, hormone, cytokine problems, can lead to premature ejaculation - since it doesn’t take much to get a higher norepinephrine spike to trigger ejaculation.
Chronically high norepinephrine can raise blood pressure. This leads to long-term consequences, including renal dysfunction and erectile dysfunction.
What can be done is to either directly address the high norepinephrine production (e.g. with a serotonergic, anxiolytic, mood stabilizing, beta-blocking medication or others), or treat the consequences - such as adrenal fatigue (where the higher cortisol levels from treatment can help reduce via a feedback loop in the brain to lower CRH production, to lower norepinephrine levels), or treat the underlying cause of higher norepinephrine levels (which can include psychological stress, trauma, mental illness, thyroid dysfunction, hypogonadism, insulin resistance, infection or other chronic physical illness, etc.). In a way, a global treatment once assessment occurs, needs to be done. I usually don’t see a single substance (drug, hormone, or nutrient, or even herb) working. There are many entrypoints to dysfunction when a single hormone/neurotransmitter is out of whack in function. What I usually see are multiple hormone/neurotransmitter/cytokine problems as a consequence.
Default Re: High Norepinepherine & Erectile Dysfunction
How do you know you have high norepinephrine??
High norepinephrine means basically a very low level of health - libido is not even an issue here. Offcourse we are talking about plasma levels of norepinephrine, i am not sure about the effect of different levels of NE in various brain regions, and whether they correctly correlate with plasma levels- i doubt that to some extend
How many times am i supposed to pass on my story?? High norepinephrine send me to the morgue allmost.
I agree 100% with Marianco, to get a neurotransmitter out of whack you must have other problems with cytokines/neurotransmitters as well.
My story started after i took finasteride, i got low libido, ED, semen and prostate problems.
To battle this i started training like a madman. I would lift for hours a day and next day play 4-5 hours bball.
Within 2 years i regained 75% of my erectile problems and penile size, but i wanted more. I continued trainining like 5-6 hours a day, incorporating bicycling 30 km per day (including uphills) at a deadly pace and swimming and more and more lifting, power or explosive squatting and plyometrics.
Soon i faced the first overtraining period of my life. I had to stay in bed 6 straight weeks and 6 more weeks away from any sports to recover. Overtraining is not fun, you eat like a dog and feel so tired, your pulse is out of whack, you walk and in 2 minutes you feel dead tired, you cant stand still you feel like dropping down, your legs are like 50kilograms each and you cant carry them along its a complete misery (or thats what i thought untill i met with adrenal fatigue)
Soon after recovering i decided i had to do more-thinkin i was weak for this to happend to me- and adapt to a higher level of training and harder lifestyle. I would do squats and plyometrics and work in a restaurant more than the previous 2-3 days a week and stay out at night and not care about my body at all. I wanted to punish it.
Drinking coffees, beating my self in the gym and in bball court and not resting after work, i ended up with the second bout of overtraining which soon ended up in adrenal fatigue.
At testing my norepniphrine levels they were found like 10 times normal while standing. Docs thought how could i be alive??? They thought i was under extreme stress and it was sooo true. I couldnt basically get out of bed for 8 straight months. Just stayed there, was fed in bed, and all i did was watch tv with brightness of 10% normal since any little stress would drive me nuts. Bright lights, noises, carbohydrates, so many things affecting me. My whole autonomous nervous system was out of whack, i started developing infections, fungi all over my body, etc etc and to battle the leg soreness (heavy leg feeling) i had to take ice baths for 6 straight months day after day.
Finally i started to get a bit better after being hospitalized and with the use of valium, and complete change of my diet. (that was at around month 8 or 9) Then i started taking isocort/ hydrocortisone and so on because i wanted to prove doctors wrong about my state. I was looking at the end result back then (being adrenal dysfunction- instead of the route problem >> high noradrenaline.low testo and cytokines messed up) I dont know if i could have ever corrected all this if i totally trusted doctors who prescribed SSRIs… Who knows???
I have made many mistakes, and found very very very few people to help me correct them. Actually noone did i think, thats why i ended up worse. I could have recovered completely but this loooong period of relentless pain and stress made me think incovrrectly and in the end being eager i jumped into wrong solutions. Probably some good long lasting diet and life style change along with some diazepam or some other substance could have helped me recover properly but i think that now i look back and thing everything is so easy but its not.
I tottally agree with Marianco, there could not be one simple substance that can help you lower noradrenaline ( i have tried more than 20 different supplements in combinations and didnt succeed)
You need a very thorough investigation to see whats wrong with your body, total available neurotransmitter testing, hormones and cytokines (if you can test for them) to evaluate properly whats going on. Unless you know exactly how and what messed you up initially, if this is straightforward then you can pretty much be helped. But if you have complicated issues like overtraining/autonomic dysfunction/immune and adrenal issues then GOD help!!
Last edited by s0b; 01-15-2009 at 08:56 AM.
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