Therapeutic potential of pyruvate therapy for mitochondrial diseases

Guys I am collecting info about SawPalmetto which I will give to a Doctor at Ottawa hospital ( I don’t if he is serious or not). I found that saw palmetto works on mitochondria of the cells. here is a quote

ncbi.nlm.nih.gov/pubmed/19154468

RESULTS: Cells treated with Sr underwent massive vacuolization and cytosolic condensation, followed by cell death only in the prostate lines. Within minutes of adding Sr to prostate cells, it caused opening of the permeability transition pore (PTP), which led to complete mitochondrial depolarization within 2 h, and to the appearance of small, pycnotic mitochondria. Release of cytochrome c and SMAC/Diablo to the cytosol was detectable after 4 h of treatment, while caspase 9 activation and poly(ADP-ribose) polymerase 1 cleavage occurred at 16 h, followed by appearance of a sub-G1 peak and apoptosis at 24 h.

CONCLUSION: Sr selectively induces apoptotic cell death of prostate cancer cells through the intrinsic pathway, and activation of the mitochondrial PTP might play a central role in this process.

I also read Therapeutic potential of pyruvate therapy for mitochondrial diseases. I am interested if any body has heard or tried it.

thanks
sps