Theory for androgen receptor resensitization and AR increase

General Discussion
#1

Androgen desensitization:

I think this might be due to the specificity of binding between the two hormones DHT and T.

Testosterone binds and dissociates faster than DHT to the AR. Which means there will be more occurance of binding incidents.

Since your body isn’t used to so much binding to the AR it desensitizes the receptors and reduces receptor formation. Its comparable to drug tolerance

(Infor on drug tolerance here. erowid.org/ask/ask.php?ID=1794)

I don’t know if everyone has receptor desensitization or not but.

I think that you can resensitize receptors of chemicals by promoting use of an antagonist of the receptor. An antagonist is a drug which acts as a competative inhibitor of the receptor site. These competative inhibitors do not form a ligand-protein complex with the AR and also do not produce a signal when bound to the receptor.

This type of interferance with the androgen receptor might cause a resensitization of the receptor to DHT and testosterone by increasing the amount of AR’s and increasing the signals they produce when androgen hormones bind to them.

here is another link to an explaination of drug addiction and withdrawl symptoms:

utexas.edu/research/asrec/dopamine.html

Neurons can become sensitized or desensitized to dopamine
One important aspect of drug addiction is how cells adapt to previous drug exposure.

For example, long-term treatment with dopamine antagonists increases the number of dopamine receptors. This happens as the nervous system tries to make up for less stimulation of the receptors by dopamine itself. Likewise, the receptors themselves become more sensitive to dopamine. Both are examples of the same process, called sensitization.

I’ve told golf(add numbers here) that saw palmetto is such an antagonist. It apparently has an ability to reduce signaling in the prostate by up to 50%

Studies in the lab haven’t proven with consistant results if saw palmetto extract causes 5aR inhibition or not. It may be because of genetics, may be faulty test results, I have no idea. I know some studies have shown that it produces no reduction in serum DHT, other studies have shown that it reduces DHT in the prostate, some studies saying it reduces serum DHT up to 20% and so on so forth.

Just a theory, any thoughts?

1 Like
#2

Some on this board have theorized the l-carnitine can upregulate AR.

propeciahelp.com/forum/viewt … f59781dc1d

I’ve had some success with it. It has been shown to increase the effect of Viagra:

altmedicine.about.com/cs/conditi … ysfunc.htm

#3

Maybe Ill give it a shot, seems like if it upregulates receptors the size of ones junk might increase. I dont get though how a large influx of testosterone would really be good if the androgen receptor is down regulated and desensitized. Seems like introducing too much T into the system could exacerbate the problem especially if the 5aR gene expression is damaged. It seems like if testosterone was in large amounts the downstream signallers, T =>DHT => Nitric Oxide => cGMP would be more abundant and would produce a better response to viagra.

BTW I used saw palmetto for a long time (round 3 and 1/2 years) in conjunction with fish oils and L-arginine and a whole slew of other things.

Functionality came back, took about 3 years to be 80%, still missing about an inch; inch and a half and libido. Marked improvement in DHT levels, feel less girly and popping veins like a mad man, breaking out, voice deepening etc.

Thanks for the suggestion, maybe this will help me on my expidition to find where the lost libido lies.

#4

[quote="jbreinho

BTW I used saw palmetto for a long time (round 3 and 1/2 years) in conjunction with fish oils and L-arginine and a whole slew of other things.

Functionality came back, took about 3 years to be 80%, still missing about an inch; inch and a half and libido. Marked improvement in DHT levels, feel less girly and popping veins like a mad man, breaking out, voice deepening etc.

Thanks for the suggestion, maybe this will help me on my expidition to find where the lost libido lies.[/quote]

you took SP? what do you mean by “round 3 and 1/2 years)”?
u did not take any fin?
what did u do to treat your SP problems?
what were your symptoms exactly?
what were you using liquid or berry powder? 320 mg?

could you pm me?

thanx

#5

Jbreinho, can you update us on your progress with saw palmetto?

Also, along the same line of reasoning of re-sensitizing the body to DHT and Testosterone, are there any known Testosterone blockers? One could hypothetically take a T blocker with a short half-life at night, in order to increase Androgen Receptor density.

#6

DIM is an AR antagonist, possibly it could be used for AR resensitiation and AR increase. It also has the benefit of altering your estrogen metabolism to reduce E2.

#7

That’s interesting, however its use in cancer therapy induces apoptosis, or cell death, as well as a bunch of other genetic behavior. Seems like a more selective anti-androgen would be a safer bet.