Theoretical discussions related to IHP's story

venceremos · May 25, 2018, 7:03am

Xhorndog:

http://www.ncbi.nlm.nih.gov/pubmed/22109896

[Size=4]Leaky gut and autoimmune diseases.
[/size]Fasano A.
Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA. afasano@mbrc.umaryland.edu
Abstract
Autoimmune diseases are characterized by tissue damage and loss of function due to an immune response that is directed against specific organs. This review is focused on the role of impaired intestinal barrier function on autoimmune pathogenesis. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiologic modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the zonulin pathway is deregulated in genetically susceptible individuals, autoimmune disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by re-establishing the zonulin-dependent intestinal barrier function. Both animal models and recent clinical evidence support this new paradigm and provide the rationale for innovative approaches to prevent and treat autoimmune diseases.

[Size=4]Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.[/size]
Fasano A.
Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. afasano@mbrc.umaryland.edu
Abstract
The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients and to electrolytes and water homeostasis. A more attentive analysis of the anatomic and functional arrangement of the gastrointestinal tract, however, suggests that another extremely important function of this organ is its ability to regulate the trafficking of macromolecules between the environment and the host through a barrier mechanism. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiological modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the finely tuned zonulin pathway is deregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune, inflammatory, and neoplastic disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by reestablishing the zonulin-dependent intestinal barrier function. This review is timely given the increased interest in the role of a “leaky gut” in the pathogenesis of several pathological conditions targeting both the intestine and extraintestinal organs.

PubMed.com search results for Zonulin (protein marker of intestinal permeability / leaky gut): ncbi.nlm.nih.gov/pubmed?term=zonulin

VERY Interesting!!! Especially as a sufferer of chronic inflammatory “abacterial” (or more aptly “idiopathic”) prostatitis - autoimmunity is a possibility.

propeciAUS · May 25, 2018, 7:03am

venceremos:

Stop posting about bullshit such as “leaky gut” or “candida” that have NO scientific bases whatsoever, please. I googled “leaky gut” and found an obvious spam/infomercial by a “holistic” quack trying to sell a “cure” for this BS “syndrome” (complete with BS detox protocols etc) leakygutcure.com/ We also have proven a long time ago that “candida” is nothing but a quacks invention to sell you BS “natural” cures to what would be the source of all illnesses : just google “candida” and you’ll see how the first search result pages are nothing but full-on snake oil BS and quackery. It’s therefore obvious that these “illnesses” or “pathogens” brought about by a dysegulation of the “immune system” (wtf is that again??) have NOTHING to do with our conditions and are nothing but quacks inventions that do not even exist in the science-based medical world. Only the most serious sounding epigenetics and androgen receptor based malfunctions can be relevant to our condition. Look how hard it is to find these terms outside of real scientific litterature! Isnt it enough proof for you uneducated dumbasses?

Mate, firstly, if you don’t believe that there’s a potential cure to PFS through diet then that’s your choice. But no need to launch into into yet another pointless argument. The REAL problem with the Theories section is when people decide to waste their time rubbishing theories and abusing people.

Secondly, read some of the links that people like Xhorndog have been posting. They’re informative, are written by nutritionists/neurologists etc that aren’t trying to flog some product, and they DO have scientific backing and are clearly showing the link between the gut and hormones, neurotransmitters, and the like.

Even if we don’t have candida or leaky gut, there’s evidence to suggest that strict dieting can resolve our issues over time. It happened for IHP. The creator of the GAPS diet (a brain surgeon, from memory?) managed to cure her son of autism, and countless others of neurological issues. In the past, if you’d have told me that diet could cure autism, I’d have punched you in the face and told you that you’re a moron.

I believe that, if nothing else, the diet and protocol that IHP put in place put his body into heal mode.

Now, for the record, let me state that I firmly believe I have PFS. Finasteride fucked me up, and I have never been the same since. It did something so sinister to me that the act of simply quitting the drug was not sufficient to make my symptoms go away. That much is true. And I’m sure that the molecular study will identify what it is that is wrong. But if someone can cure MS with diet, autism with diet, cancer with diet, then why can’t we cure PFS with diet too?

ANNNNNNND Now that I posted that, you’ve mentioned that you were being sarcastic. Sorry, I didn’t catch that sarcasm at the time even tho English is the only language I speak!

visionquest99 · May 25, 2018, 7:03am

dgreene · May 25, 2018, 7:03am

Mew can you please give us a link to the research that is currently taking place? Every research study has a submitted abstract that is available for public viewing. It should be on pubmed, I have been looking but I can’t find it.

Xhorndog · May 25, 2018, 7:03am

Amen! Ditto! Yes! Hope so!

Second_Amendment · May 25, 2018, 7:03am

It won’t be on pubmed until it’s published. The scientists need credit for their work.

tim1911 · May 25, 2018, 7:03am

Thanks Mew.

Second_Amendment · May 25, 2018, 7:03am

This is a serious forum where lives are at stake. Go to myspace if you want to act like a jackass.

bryce54 · May 25, 2018, 7:03am

bryce54 · May 25, 2018, 7:03am

venceremos:

Stop posting about bullshit such as “leaky gut” or “candida” that have NO scientific bases whatsoever, please. I googled “leaky gut” and found an obvious spam/infomercial by a “holistic” quack trying to sell a “cure” for this BS “syndrome” (complete with BS detox protocols etc) leakygutcure.com/ We also have proven a long time ago that “candida” is nothing but a quacks invention to sell you BS “natural” cures to what would be the source of all illnesses : just google “candida” and you’ll see how the first search result pages are nothing but full-on snake oil BS and quackery. It’s therefore obvious that these “illnesses” or “pathogens” brought about by a dysegulation of the “immune system” (wtf is that again??) have NOTHING to do with our conditions and are nothing but quacks inventions that do not even exist in the science-based medical world. Only the most serious sounding epigenetics and androgen receptor based malfunctions can be relevant to our condition. Look how hard it is to find these terms outside of real scientific litterature! Isnt it enough proof for you uneducated dumbasses?

Just an FYI, Google uses a certain algorithm in order to rank websites on the front page for certain keywords. There’s ways to manipulate it and get yourself onto the top 10 on Google. That website you found is simply someone who made it, ranked it themselves, and then is trying to sell something to people who search for leaky gut. In no way can you use the ranks on Google to determine if something is quackery or not.

Second_Amendment · May 25, 2018, 7:03am

third person unable to detect the irony

Xhorndog · May 25, 2018, 7:03am

venceremos:

Xhorndog:

http://www.ncbi.nlm.nih.gov/pubmed/22109896

[Size=4]Leaky gut and autoimmune diseases.
[/size]Fasano A.
Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA. afasano@mbrc.umaryland.edu
Abstract
Autoimmune diseases are characterized by tissue damage and loss of function due to an immune response that is directed against specific organs. This review is focused on the role of impaired intestinal barrier function on autoimmune pathogenesis. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiologic modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the zonulin pathway is deregulated in genetically susceptible individuals, autoimmune disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by re-establishing the zonulin-dependent intestinal barrier function. Both animal models and recent clinical evidence support this new paradigm and provide the rationale for innovative approaches to prevent and treat autoimmune diseases.

[Size=4]Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.[/size]
Fasano A.
Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. afasano@mbrc.umaryland.edu
Abstract
The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients and to electrolytes and water homeostasis. A more attentive analysis of the anatomic and functional arrangement of the gastrointestinal tract, however, suggests that another extremely important function of this organ is its ability to regulate the trafficking of macromolecules between the environment and the host through a barrier mechanism. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiological modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the finely tuned zonulin pathway is deregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune, inflammatory, and neoplastic disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by reestablishing the zonulin-dependent intestinal barrier function. This review is timely given the increased interest in the role of a “leaky gut” in the pathogenesis of several pathological conditions targeting both the intestine and extraintestinal organs.

PubMed.com search results for Zonulin (protein marker of intestinal permeability / leaky gut): ncbi.nlm.nih.gov/pubmed?term=zonulin

VERY Interesting!!! Especially as a sufferer of chronic inflammatory “abacterial” (or more aptly “idiopathic”) prostatitis - autoimmunity is a possibility.

Does anyone who is currently seeing a doctor have any desire to do the Zonulin test?

tim1911 · May 25, 2018, 7:03am

lol, if you say so.

dgreene · May 25, 2018, 7:03am

It’s not a matter of getting credit. It is recognized that you’re working on the research project when you submit an abstract. THis is how research works. Every research study starts with an abstract that is available for public viewing. Can someone please just send the link or something?

Second_Amendment · May 25, 2018, 7:03am

No it doesn’t

venceremos · May 25, 2018, 7:03am

Well an abtract, by definition, is indeed only made when the study has been fully completed, conclusions have been drawn, and it is ready for publishing. Its therefore only available when the study has been published.
I guess Drgreene refers to something similar to this clinicaltrials.gov/ which indexes ongoing or completed, currently recruiting or not clinical trials, but I think these informations are only shared on a voluntary basis, if Awor’s team doesnt want to make their study (not a trial) known to the public before its completion, they do not have to, obviously.

I dont know which is the university where the study is being conducted, but they probably have a database of ongoing studies where it can be find if possible (such as this clinicalstudies.info.nih.gov/ )

braziliandude · May 25, 2018, 7:03am

hahahhaha

bostonusa2009 · May 25, 2018, 7:04am

Boston2009: Your whole post was a quote of DutSucks making a case for candida infection which you supported with a faulty analogy - calling people against it uneducated. It’s disingenuous to claim that you were only making a case for how dangerous mold is, especially because the mold in question is a different species than candida and lives in a different environment altogether.

boston2009 wrote:
In my opinion anyone that argues against it, hasn’t taken the time to really educate themselves to the facts. I’ll admit when someone first mentioned the Candida idea on this forum, I though it was far fetched this could cause all of our problems. If anyone thinks it’s far fetched the are Ignorant.

I mentioned this to reiterate something that Xhorndog stated, we will never eliminate yeast from our bodies, it’s an essential part of our physiology. Candida is a mutated form of yeast and there hasn’t been a single diagnosed case here, less blood microscopy results.

Or has there?

“A diagnosed Case” You have to be kidding me. After everything you have been through with MD’s, you need a doctor to diagnose you as having a Yeast overgrowth to believe it’s a reality. Your obvious goal seems to become a “Moderator” on this forum or simply a cheerleader for Awor’s theory. Maybe it’s best that we agree to disagree, because you and I are going in completely different directions.

tim1911 · May 25, 2018, 7:04am

Sorry xhorndog, where did you get this information from? Might be really obvious and i may have missed it.

Xhorndog · May 25, 2018, 7:04am

Tim, unfortunately, I don’t recall. It was something I’d rehashed from some old research/brainstorming. I realize that supposedly fin does not affect P450 metabolism. I don’t ultimately know if that’s true or not.