This is retinoic acid signaling and synthesis.
Aldehyde dehydrogenase 1 family, member A1 , also known as ALDH1A1 or retinaldehyde dehydrogenase 1 (RALDH1)
RALDH1 (ALDH1A1) was the first member of the ALDH family found to possess in vitro activity for oxidation of retinal- dehyde to RA (18, 20). … Our results indicate that RALDH1 plays a role in oxidation of retinaldehyde to RA for clearance of excess retinol in adult mice, thus acting downstream of ADH1
We have described a 56 kDa protein from genital skin fibroblasts that specifically binds androgen and that is generally not expressed in genital skin fibroblasts from patients with androgen insensitivity due to genetic defects of the androgen receptor. We have isolated a partial cDNA clone for the 56 kDa protein from an expression library of genital skin fibroblasts. In vitro translation of message selected with this clone faithfully produces the 56 kDa protein which can be immunoprecipitated with an anti-56 kDa antiserum. Northern blots probed with this clone show a 2.2 kb message, which parallels the expression of the 56 kDa protein. The sequence of this 998bp clone is identical to human liver aldehyde dehydrogenase 1, the cytoplasmic isoenzyme. On activity gels of genital skin fibroblast cytosol covalently labelled with androgen, aldehyde dehydrogenase activity comigrates with the single band labelled specifically with androgen. Thus, the 56 kDa androgen binding protein is an aldehyde dehydrogenase, which is prominently expressed in normal genital skin fibroblasts, but not in non-genital skin fibroblasts.
You see how closely these two could work together.
Sex specific retinoic acid signaling is required for the initiation of urogenital sinus bud development
These data identify RA as a major player in the initiation of prostate development, together with androgens.
We show that sex specific retinoic acid is required for male UGS bud initiation.
An increase in retinoic acid can lead to prostate-like formation in females.