“Finasteride inhibits the conversion of testosterone to DHT, but it also changes testosterone, LH and FSH levels. The biosynthesis of DHT and various neurosteroids, such as allopregnanolone and tetrahydrodeoxycorticosterone, are dependent on known isoforms of 5α reductase. They are positive allosteric modulators of the GABA A receptors, which have the same site of action as euphoric and anxiety-relieving drugs such as benzodiazepines. Since finasteride has been shown to inhibit their biosynthesis, and patients with PFS have decreased or increased levels of some neurosteroids, this effect is one of the possible causes of the emotional and sexual side effects.”
Could this be the reason why some of us don’t respond to meds like Benzos or don’t get euphoria from drugs that binds often on GABA receptors?
Some of us also have improvements after being “drunken”, alcohol increase GABA trough his agonism on it, so this would explain the windows after it?