Review everything in this thread. Mechanism-based inactivator (Finasteride) = suicide inhibitor.
sps, thats what im saying, but i dont know and it most certainly cant be ruled out, even with high dht.
Interesting that penicillin is a suicide inhibitor, I’m allergic to it.
how with high DHT? when DHT is there that means 5ARs are working their job.Am I worong?
Ok if once 5ARs are bound irreversibly their number decrease? our body does not create more 5ARs? Does number of 5ARs rema in the same in the body through out life?
Also if it is because of 5ARs permanent inhibition then we can try SARMs to test this theory?
Under normal circumstances the body will synthesize new 5AR enzymes within a week or 2.
Lets be a little more specific here, i am not talking about 5ars in general, i am talking about type 2 5ar.
The major population of this enzyme is found in the male prostate. Going off the study that oscar posted viewtopic.php?f=9&t=5451 5ar2 reduced dihydrotestosterone in not a major contributor to circulating blood levels.
Therefore the majority of dht in the blood is from type 1 5-alpha reductase. Bringing me to the conclusion that there is a possibility we are 5ar2 deficient.
how do you know. have you studied biology or other source?
Lets be a little more specific here, i am not talking about 5ars in general, i am talking about type 2 5ar.
The major population of this enzyme is found in the male prostate. Going off the study that oscar posted viewtopic.php?f=9&t=5451 5ar2 reduced dihydrotestosterone in not a major contributor to circulating blood levels.
Therefore the majority of dht in the blood is from type 1 5-alpha reductase. Bringing me to the conclusion that there is a possibility we are 5ar2 deficient.
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so then we should inject 5ar2? At least it will tell us what the problem is?
Is that even possible. Im not sure it would go to the right places, this kind of biology is far beyond me.
If you could find the dht value of the prostate only, or the value of the effected neurosteroids, that may offer a clue.
Many on this forum believe adiol-g is a marker for 5ar2 in the prostate, and that doesnt look good for guys.
Also eveyone who has had the 5ar2 metabalites urine ratio test has come back showing a deficiency, everyone who used finasteride anyway.
ok if that is injecting is not possible then can we use SARMs? SARMs will by pass 5ARs and will tell us whether problem is in 5ARs or in the receptors. Also if 5ARs are regenerated then what about receptors? I have read saw palmetto binds to AR receptors as well, maybe that is true for fin and dut too. So may be these compound have bound irreversibly to our receptors.
Also do our AR receports regenerate of the number remain the same thoughout our lives. .I am not good in biology.
provide a source when posting stuff like this.