I don’t want to particularly add anything further to this debate; but, I will say that my first post was problematic in that it was horribly unsubstantiated. I really didn’t feel that Mew was rude. I went on to provide the scientific validation that I should have initially included. I will add however; that Finasteride is indeed a lipophillic (fat-liking) compound that is converted into a more readily excretible product by the liver. Now given that the liver must do this every single day when you ingest the drug for sometimes years on end; it is fathomable that on one of those many occasions; and, as the liver is involved in numerous other processes, that the process could falter; and, the chemical alteration does not occur.
The following is taken from the Merck Manual: it reads
“The liver’s primary mechanism for metabolizing drugs is via a specific group of cytochrome P-450 enzymes. The level of the cytochrome P-450 enzyme controls the rate at which many drugs are metabolized. The capacity of the enzymes to metabolize is limited, so they can become overloaded when blood levels of a drug are high.”