The first Trial with SAGE-217

Therapeutic Efforts Pharmaceutical
#207

My PFS doc has tried the pill form of oral progesterone which is given to women, and he says that it does not work for me. Wondering if this is analogous to the pill form of allopregnanolone/brexanalone, aka SAGE217.

**Maybe this neurosteroid needs to be given by IV to get past the blood brain barrier!

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#208

I think the IV version cost $30,000 and that doesn’t include the hospital stay. But I agree the IV might have a better effect.

#210

I don’t know if anybody has asked Melcangi about this but it makes sense that it could help. It’s the one biochemical that has been consistently shown to be depleted among all PFS patients that have been tested, even if its a small sample. If that doesn’t make sense to try, then it doesn’t make sense for anybody to try any other treatment.

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#212

literally no one except 2-3 folks thought sage would cure their sexual side affects

the rest of us want to sleep a little better and have less brain fog from it lmao

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#213

Some points to make -

It is very common in medicine to not know exactly what mechanism enables a medication to work but through testing and experience they know it does.

That being said, there has been a decent amount of animal studies with allopregnanolone that indicate there is a link between sexual function and neurosteroids. There is a mechanistic connection there to think it may help us, but we have one data point for whom it did not work.

This isn’t a depression pill, it’s an allopregnanolone pill that is being tested to see if it works for a handful of medical conditions. Time will tell if it works. There are too few PFS patients to do a clinical trial, but that doesn’t mean it won’t work.

Here’s one study as an example for why allo may be involved in mechanistically regulating sexual functioning. Of course rat studies may not translate to human studies, but the link suggests its worth exploring in PFS.

https://onlinelibrary.wiley.com/doi/full/10.2164/jandrol.108.005660

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#214

Things aren’t looking so good for Sage atm:

Sage Therapeutics is also testing another PAM of GABA-A, Sage-324, probably another neurosteroid analog.

On the upside, $SAGE chart seems to have bottomed.

#215

It won’t cure us anyway. Just could be “beneficial.” That’s all imo.

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#216

i wouldnt make too much of it based off that analysis article

that being said, im neutral in terms of hope of sage passing trials or not