The dark side of 5α-reductase inhibitors' therapy

fuck man…

How’s it still available?

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Easy they blame cancer, age, and cancer treatment for all the fin. sides. Most of these people die within a few years and are older. No casual link to just fin.

Who has read this study? Currently reading.

It’s been posted several times, but I was curious what the current view on it is

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It has recently been shown that patients who had been treated with finasteride have reduced or undetectable levels of neuroactive steroids in their cerebro-spinal fluid and plasma, and exhibited higher levels of precursor steroids [75]. This observation strongly suggests that 5α-RIs have a deleterious effect on the biosynthesis and function of neurosteroids in the central nervous system. Finasteride treatment resulted in decreased levels of 5α-DHT and 3α, 5α-tetrahydroprogesterone (AP) and increased levels of testosterone supporting the hypothesis that deleterious effects of finasteride may be persistent or irreversible. This may explain some of the noted symptoms such as anxiety, depression and suicide in patients who have been treated with finasteride [76].

Concomitant with these changes are the markedly reduced expression of neuronal nNOS and increased expression of the inducible NOS, suggesting that dutasteride induces altered gene expression in the corpus cavernosum. Oztekin et al. [38] investigated the effects of dutasteride on erectile function after 6 weeks of treatment followed by a washout period of 2 weeks. The ratio of ICP over mean arterial pressure [MAP] and total ICP in the dutasteride treated animals were significantly decreased when compared with control animals (Fig. 2). Even after two-week washout period the effects persisted and the ICP/MAP was significantly reduced in the dutasteride treated animal, suggesting a persistent effect of the drug on erectile physiology