Has anyone else tried this? I will do it if I seriously head toward suicide. It is worth a shot then.
if anybody wrongly decide to taking finasteride again, do this with rifampin…
I also wonder the same thing. Some people pointed out there were few recoveries with taking Iso. again on acne. org forum. Also heard some few recoveries from another forums if im not mistaken. I really wonder what will happen if i take the drug again, not that i ever will.
Where this theory fits into? How taking Fin/Iso again can cure us? If they downregulate AR’s, how taking them again can cause upregulation? Can anyone just help me to understand the mechanism?
1 Like
Basically taking an anti-androgenic substances will reduce AR signaling within cells. In some tissues, the body compensates to reduced AR signalling by up-regulating the androgen receptor (increasing the amount of receptor). When we quit taking finasteride, Isotretinoin or SP abruptly androgens signaling starts again. However the receptor is up-regulated and therefore too much signaling occurs all at once and the body reacts by preventing further signaling via an unknown mechanism (epigenetics, silencing etc). Once our hormones stabilize unfortunately the receptors don’t go back to normal, why this occurs we don’t know.
The theory is if we reinstate the drug and reduce androgen signaling again the body recognises this amount as the correct level of androgen signalling and unsilence the receptor. This is why we think some feel better when taking anti-androgenic substances after getting PFS. If we slowly tapper off the drug again rather than stopping suddenly our body and cells slowly ‘adapt’ to the new level of androgen signalling over a period of days/weeks. Tapering should continue until you’re completely off the drug.
gimzim, denarion, a dude on the other forum (jack17) and some guy on reddit are the people who have had success that i know of.
1 Like
I did this and it didn’t work… Felt pretty good the first 3 days but in the end the effects disappeared and I was back to baseline.
Yeah all hypothetical would not recommend, i think most people just get a temporary improvement and then back to baseline or worse.
1 Like
Did this and got worse, it’s not a good idea trust me. And this is from a guy taking an ssri
Did you taper off the second time or cold turkey?
Anyway i agree the risk reward is just way off i just hope somehow in the future they can develop a PFS animal model which might help us answer some of these important questions.
I did .25mg every other day for weeks, then to .25mg very day for months then tried 1mg every day and instantly got hit with terrible brain fog and derealization, depression, everything but worse sexual sides. When I stopped I went back to .25mg for a while then stopped. It gave me new mental sides the second time that have yet to get fully better
The first time I took it I mainly got sexual sides but started to get bad anxiety as well after a year that went away until I tried it again years later as described above
Thanks for the response sorry you got burnt twice, I hope you find some healing in the years to come
2 Likes
Thanks for the kind words, it was my own fault having already had pfs and trying it again. I was of the mindset that I was already feeling zero sexual pleasure so what could get worse, well it can always get worse. I’m down with encouraging out of the box protocols but this ain’t it trust me
1 Like
Can you please describe those good effects in detail? Especially for your sexual sides? Thanks.
Don’t ever think about using finasteride , your sympthoms induced by accutane will get 10 times worse , you’re only a mild case cooper , you’ll get it right and things will improve so don’t make some stupid decisions like taking finasteride or any other similar drug @Cooper
2 Likes
I crashed within days of my first dose of finasteride, so I think there is some difference between those who crash quickly when on it, and those who crash when they stop. I will never touch it again, ever.
3 Likes
I took it on and off for years without knowing the cause of my worsening health, crashing many times and never getting better. That’s why I have everything in the book. It would be the worst decision/risk
2 Likes
I crashed 2 months after i stoped and my sympthoms are similar to yours , i’m not sure it makes much difference to be honest
2 Likes
Our own guy Axolotl (if I remember his story correctly) took a low dose of fin and got PFS symptoms. Then I think a single further dose caused a huge multitude of symptoms and further worsened him. That doesn’t seem isolated either.
I’m one of the folks who’ll try any old mad protocol with half a concept behind it, but I’d have to be REALLY desperate to take a pill of fin again.
3 Likes
@PFS25 yeh but imagine taking it again in effect that’s what I’ve done. I had two year off at one point when I was after a family this was post test cancer courtesy of fin. I believe I would have got away with a few sides only from the first run of it. 18 years is insane. I just don’t think I would have been a severe case that’s all. It took 8 years to develop tinnitus which is generally an early symptom up to that point I had anxiety, insomnia and partial libido issues
2 Likes
Did you take it non-stop for the first 10 years ?