I was just thinking about the 5AR2 enzyme…does anyone know if it has it ever been manufactured in a lab? Enzymes are biological catalysts and all catalysts cause ‘chemical reactions to take place’ (T to DHT among other things in this case). A property of all enzymes is that they remain chemically unchanged after the reaction(s) they help to cause have taken place. This makes me think that 5AR2 (as an enzyme) is quite a stable, unreactive molecule that could be taken without being broken down by the body. Therefore, has taking synthetic 5AR2 (if it exists) ever been considered by anyone???
Just a thought.
Where have you read this? Do you have a study to prove this point? I’m interested to learn more.
Thing is, 5AR requires binding to NADPH in order to irreversibly convert T --> DHT.
If NADPH is damaged, it leads to an unstable enzyme complex such that 5AR would likely not work correctly anymore. I proposed this theory here:
propeciahelp.com/forum/viewtopic.php?t=1401
Since Finasteride binds to NADPH instead of Testosterone (when you take it), maybe this could also a source of the problem, post-Finasteride.
I might of know there’d be more chemistry involved…what is NADPH? My ‘catalyst’ comment is not much more than a ‘high school definition’, Mew. No one has tried synthetic 5AR2 as a therapy right?