Definitely this report is the best. Extraordinarily high level, but we can see the outline of PFS. I have great admiration for this work.
By the way, I have a question.
It shows that overexpressed AR cannot work normaly and it causes every symptoms. – I understand.
Finasteride deprives us of androgens. It is quite natural that deprivation of androgens can bring AR (epigenetically) overexpressed. – Absolutely.
So, after cessation of fin, harmful severe symptoms should happen. It is inevitable.-- It’s OK.
My question is why AR-overexpression can not return to normal with time.
Just because it is epigenetic? or a special epigenetic modification as a kind of aging irreversible process?
is there any hypothesis about it? or no idea?
If anyone knows, please teach me.
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I have one more question.
According to the researches, AR-overexpression itself is destructive disaster for our life system. And it is probably inevitable for everyone that finasteride brings AR overexpressed. Because it deprives us of androgen.
So, why is it that only few people fall into PFS?
If AR-overexpression itself is the cause of PFS, no one can avoid it. Don’t you think so? Or, for most people finasteride does not increase their AR?
If anyone knows, please tell me why.
if it is that when androgen came back after the cessation of fin, under the condition of AR-overexpression something(X) which causes PFS happens only in few unlucky prople, I can understand it. In this case, AR-overexpression is not the cause but one condition. And the true cause(X) should prevent AR from returning to normal. (But this assumption may be not true.)
Or, AR-overexpression caused by finasteride immediately returns to normal after cessation of the drug in the case of most people, but doesn’t so in few people because of their predisposition. Is this the reason?