Study updates

Science PFS Research
#7

I am talking about Boston and Texas studies. Anyone in touch with them?
I really hope this is not another non-result, or maybe worse, they will simply find some genetical differences between us and those who do not get PFS…and then what do we do…

Sorry for trying to anticipate, but I am like many of you, can’t deal with this anymore. On another note, a girl is visiting me soon, but I am in a bad period, anything you recommend to maximize my chances? I re-started Progesterone as that typically helps…

#8

I realized this month that me and my older brother both have taken finasteride yet he has not had any problems and I have. We may just be the ideal two to research about. I would be willing to pay for him to fly with me to be involved in a study.

#9

Numbduck, do you take test boosters? Don’t worry about cycling for now and just take Tongkat Ali everyday until you see her. I took it everyday once for a month a half and the results were still great. Or just take 2 days off a week if you’re really worried about your body getting used to it.

#10

I went to Baylor but have not gotten back my genetic testing yet. Has anyone who went there gotten theirs back?

#11

Could someone explain that with this genetic testing, they can see any genes that are switched off or on in the body? Or is this specific only on the tissue where its taken from. So if this test comes out andwe have no genetic changes we are 100 percent sure this isn’t genetic or there are still possibilities and other areas to look for genetic changes?

#12

Are they testing to see if the 5ar enzymes is operating optimaly?

#13

I would also appreciate an explanation. What I understand about the genetic testing is very elementary.

#14

this would be interesting!

#15

Yep my brother never had a crash and is running like a champ and to be honest we are very similar. I would like to see what the major differences between me and him are that might shed a clue. Without a study willing to do it im shit out of luck cause dr here in canada only know what they can read from a book.

#16

Just found out that out of the three 5ar enzyme types, the Milano study is only investigating type 1 which happens to be the enzyme which is least influenced by finasteride. I do not understand the logic

#17

I wonder how you determined that. But not super important. The other two studies are focusing more on the receptors. The Italians primarily on neurosteroids.

#18

An email from the research lead:

“among the different isoenzymes we will analyze only the type 1. Of course also the others are interesting, but is a problem of budget available and of the number of researchers involved in our team.”

If anything, priority should be given to investigating mutations of SRD5A2, then mutations of SRD5A3, then whatever else

#19

Dr. Melcangi wrote back:

"Type 1 is also affected. The discussion the finasteride is selective for type 2 is more in the prostate. On the contrary type 1 is very expressed in nervous system. "

#20

This is why we should be donating to the Foundation even if it’s $5-10 a month like some have suggested. Think of the money people have spent on homebrew that hasn’t made a difference. Many of us still work and earn an income, we need to be doing more on the donation side of things and not take the Foundation for granted. Nobody wants to be living with this problem 20 years from now.

#21

This post has reminded me of donating to the foundation. The last two months I forgot to donate, so today I have just made a donation, and my plan is to donate each month part of my salary. From now on I will make an automatic transfer each month to the foundation, and I encourage everyone of you to make this.

One single person can’t do anything. Some hundreds of people donating each month can suppose the end of PFS in a few years.

#22

Use “Amazon Smile” and donate everytime you buy something on Amazon too.

#23

It’s tax deductible for god’s sake. We need to figure out a better way to increase funds.

Can someone please explain the logic behind testing type 1 and not type 2 or even 3?

#24

I would not bother pestering Melcangi. This guy is ridiculously qualified when it comes to neurosteroids and 5ar. I have tried to learn about this stuff from textbooks and found chapters written by him or based on his research which dates back to the 80s.

#25

Hi Guys,
I have just completed the study and I was the final participant. There is another ARM to the study which they take samples from people who have not taken finasteride. They are obtaining samples from people who are getting circumsized so they are positive about the progression of that arm of the study. Please participate earlier in future studies. This study could have been completed 18 months ago. We have an unbelievable opportunity to get our lives back We are very lucky the foundation even exists. Please stop wasting time and participate in future studies, our lives are passing us by . I also received am array of tests which I would not get otherwise and if you participate you will be able to participate in research on treatments.

#26

thanks for participating mamoo! I wish I were eligible for these studies. Hopefully we start hearing some positive results soon.