I more and more have my eyes on the role and effects of different Sirtuins (1-7) in the brain and sexuality, and here is a study that implicates Sirt4 in what some might call “PSSD”:
Sexual dysfunction and cognitive deficits are markers of the aging process. Mammalian sirtuins (SIRT), encoded by sirt 1-7 genes, are known as aging molecules which are sensitive to serotonin (5-hydroxytryptamine, 5-HT). Whether the 5-HT system...
Antidepressants like CIT [Citalopram] and fluvoxamine cause sexual dysfunction in rodents (Montejo et al., 2001 ; Soga et al., 2010 ), and human (Waldinger et al., 2001 ). Recent studies have shown that chronic SSRI treatment could decrease 5-HT content and signaling in the brain (Delgado et al., 1990 ; Hervás and Artigas, 1998 ), rather than simply facilitating synaptic 5-HT availability (de Jong et al., 2006 ; Geddes et al., 2015 ). Therefore, age-related and CIT induced sexual dysfunction and cognitive loss due to the decline in 5-HT in the POA may be mediated by an up-regulation of sirt4 gene expression.
An interesting little study.
