Some years ago awor published a summary of all the diferent studies planned. Does anyone know which of these studies are the ones currently taking place in Baylor, WBH and Italy?
This is the summary published by awor:
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Research Project Status
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Project working name: 1. AR expression in penile tissue
Objective: Determine if we have normal AR levels in penile tissue
Funding: secured
Status: Pilot is completed, project is being expanded with additional patients
Results: We found significant results (can’t detail because data is still unpublished)
Next steps: Recruit another 4 patients to increase sample size and statistical significance (in progress)
Publication: Q3/Q4 time frame
Remarks: We could use another 1-2 volunteers for completing the study. If you live in Europe, have penile insensitivity and are interested, please contact me via pm.
Project working name: 2. Full genome gene expression in penile tissue
Objective: Determine gene expression profile at a full genome level and identify potentially deregulated pathways
Funding: open
Status: Team is being finalized, protocol is in progress
Results: n/a
Next steps: Do pilot with biopsies from additional patients form project #1 (see above)
Publication: open
Remarks: If pilot yields significant data, we will launch full study as soon as we have funding
Project working name: 3. Genetics study
Objective: Find genetic markers which predict susceptibility for PFS
Funding: partially secured
Status: data analysis in progress
Results: first findings are available (can’t disclose due to publication status)
Next steps: complete analysis and write paper
Publication: open
Remarks: none
Project working name: 4. Effect of PFS on neurosteroids
Objective: Determine neurosteroid levels of affected patients
Funding: partially secured
Status: pilot in progress
Results: very significant findings (can’t disclose due to publication status)
Next steps: complete pilot and increase size of study
Publication: open
Remarks: We expect to complete pilot in June. If all goes well, we will expand study and this will require further patients. PM me if you live in Europe and are interested in participating.
Project working name: 5. Study of epigenetic effects involved in PFS
Objective: Understand mechanisms of persistency related to PFS with a focus on epigentics
Funding: open
Status: Study protocol design
Results: n/a
Next steps: finish protocol, secure funding and start patient recruitment (target: Q3)
Publication: target- approx. 12 months from study begin
Remarks: none
Project working name: 6. Proteomic study
Objective: Verify quantity and function of specific proteins encoded by androgen responsive genes (ARG’s)
Funding: open
Status: planning phase
Results: n/a
Next steps: determine team, secure funding and start protocol design
Publication: n/a
Remarks: none