Spot on @5-alpha-victim ! Couldn’t have said it any better. I echo your opinion on the “blanket approach”. I’ve been repeating myself saying that PFS isn’t a disorder of singular origin. Fin results in PFS but so does SP, AIs, SSRIs, accutane and what have you. How symptoms overlap is staggering. I wholeheartedly understand the urgent need for a universal treatment as in the case with vaccinations, but living with this disorder for so many years and experimenting with hundreds of supposedly tried-and-true supplements and whatnot have taught me this is NOT the case. That’s why I resorted to my own historical data to track down abnormalities. I tried to get bloodwork not only during my bad times but also during good times. E2 and DHEA-s were strongly correlated with my libido, motivation, assertion, assertion and well-being. It appears that increasing E2 in such a way T/E2 is balanced is the way to go for the low E2 subset of PFS.
That said, I came across many fellow sufferers with apparently high E2 but I can’t speak for them since I haven’t been there myself. I tried to do some digging about 4-DHEA and it seems it’s the synthetic version of DHEA that converts to T (and thus E2) at a more effective rate, in theory. Regular DHEA in doses of 15-25mg/d for 2-3 weeks wasn’t suppressive to T, well at least in my case, but I’m not sure how this translates to the synthetic 4-DHEA.
Is there anyone on this forum who had experience with 4-Andro/4-DHEA?