Started Aromasin 12.5 mg/day and got Pain in NIPPLES!!!!

[solonjk]

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[Ihatepropecia702]

@solonjk

Wow I am having problems with this examestane (aromasin) dosage. I am taking 12.5 mg per day for the last 3 days but failed to notice any improvement in my symptoms (testicular aches and shrinkage). In return i started having pains in my nipples too today!!! WTF!!! Why would this happen?? I am taking an anti-aromatase and i get more pains in my testicles and shrinking and new pains in my nipples that i never had. Should i be adding some dostinex to bring progesterone down too??

My original levels where 54 pg/ml of estradiol2 and very low androstanediol glucuronide 1.24 (with normal 3.5-21). Testo was 450 mg/dl

could i be needing a higher dose of aromasin ?? 25mg is one pill, i thought to start with half a pill to not make it so hard on my body.

My feeling is still that the rate of conversion to dht is so extremely low that even aromatase inhibition causes rebound rises in testosterone that bring dht up very little and estrogen back up again to a higher margin. I never had such pains in my nipples, how can they happen with the use of aromasin???

Should i increase the dose of aromasin to 25mg/day ??? or add some dostinex too?? I think this is a definate sign that this balance is fucked somehow and nothing more or less.

Hey, just wanted to let you know that I have tired all anti e, Armidex, Arromasin, and Femara, and just felt worse over time. They also made me gain some weight beleive it or not, and they made my nipple fat bigger. Just my experience with them.

[solonjk]

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[awor]

@solonjk

Yeah but why is this happening>?? Did you do some tests while on the anti-e and how long did you take this medication for??

Normally estrogen should be lowered and all the estrogen related side effects should decrease while on them… Wtf

I got the same effects with both Aromasin and Arimidex a while back. Your estrogens are not the problem, they never are the root cause in our case. Blocking aromatase will increase your androgens which seem to be aggravating your condition by increasing negative AR auto-regulation. Read the paper I sent you…

PS: I bet if you try TRT you will get the same effect - pain in your nipples - especially with Testogel. I’ll even bet that Andractim will give you the same problem.

[Mens_Rea]

TS you posted under that blog too didn’t you, the one on the main page?

As i said there - its unlikey aromasin has even did much yet. I read it takes a week to stablise in the blood. Its probably pushed your E2 levels down already though, but if you definately have high e2 i would try keep on it. Im just speculating but sometimes things get worse before they get better, even under treatment.

You case does appear one of the more complex on this board though.

Also, 25mg a day was shown to keep e2 in range in studies. If you E2 is definately high 25mg shouldn’t be a problem.

[Mens_Rea]

@awor

@solonjk

Yeah but why is this happening>?? Did you do some tests while on the anti-e and how long did you take this medication for??

Normally estrogen should be lowered and all the estrogen related side effects should decrease while on them… Wtf

I got the same effects with both Aromasin and Arimidex a while back. Your estrogens are not the problem, they never are the root cause in our case. Blocking aromatase will increase your androgens which seem to be aggravating your condition by increasing negative AR auto-regulation. Read the paper I sent you…

PS: I bet if you try TRT you will get the same effect - pain in your nipples - especially with Testogel. I’ll even bet that Andractim will give you the same problem.

Awor could you qualify that statement pls?

I reckon many people here here have simple T/E balance issues. In fact i’ve seen many people in this boat and i believe i am myself. My penile pain/shrinkage and further effects on erections etc corresponded exactly with a month where my e2 levels soared. In some cases, it is that simple.

[Mens_Rea]

solonjk is you e2 even that high?

I see posters on that other forum say to you that your levels are all okay.

If so…i dont know.

EDIT- Low SHBG too. AI’s would probably lower this further too.

You seem to be in a complicated position, man. Looking more at your issue, e2 probably isn’t the root, it’s your very look 3-adiol-G levels. Maybe awor or Mew could help you address this.

Doing other things is probably going to damage you more. You’ve tried loads of stuff already but as you know yourself, unless you;re targeting the root cause then you’re messing with things that shouldn’t be messed with which can ultimately make a bad situation worse.

You say youre considering proviron, well be aware that this will decrease SHBG too. Too mcuh of it can also shut down your Test production. You mentionted 50mg a day, this would probably be too much. Experimenting with 1 or 2 25mg doses a week for a week or two would be interesting imo.

DHT cream in the interim is the only thing i can really recommend. That, and alot of weight lifting alongside CREATINE. You do realise there is a study that says creatine increases your DHT levels like 40-60%? I’ll get that study for you if you wish. This, along with a natural gain in testosterone is probably your best chance mate. I keep saying, any recovery from an situation like yours takes baby sets, lots of sustained improvement to get your body back into sync. This would surely help.

[Y-C]

@Colin297

Doing other things is probably going to damage you more. You’ve tried loads of stuff already but as you know yourself, unless you;re targeting the root cause then you’re messing with things that shouldn’t be messed with which can ultimately make a bad situation worse.

I couldn’t agree more. My tests showed very, very low free T, pretty high SHBG, and E2 that could be lower. So I tried cycling Avena Sativa (for lowering SHBG), Chrysin, DIM (for E2), Tongkat Ali and Tribulus.

Believe me, I went to 1% libido and low penile sensitivity to 0% libido, 0% sensitivity, 0 morning wood, and empty penis.

I stopped two days ago, and I regained the 1% baseline, and a just a little fuller and a little bit more sensitive penis.

The hell with the supplements, they only make us worse.

My DHT is so damn high, I hesitate to use a DHT cream…

[Y-C]

I forgot I even added Tyrosine, phenilalanine, and Arginine in the mix

Stupid supplements, off-topic anyway (we’re in the drug/hormone section), but that confirms what Colin297 said.

[Mens_Rea]

Y-C have a look at this thread - Hypo’s post…

viewtopic.php?f=1&t=190

You might be a similar candidate.

[Y-C]

@Colin297

Y-C have a look at this thread - Hypo’s post…

viewtopic.php?f=1&t=190

You might be a similar candidate.

Thank you Colin, I will give it a thought if time doesn’t improve things (but I doubt it does).

However, I’m a little scared to take a drug for a lifetime.

But who knows, if Fin effects go on after stopping the treatment, maybe 2 or 3 years on Danazol and the effects will persist too?

[solonjk]

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[solonjk]

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[Mens_Rea]

@solonjk

I don’t know i m just trying to save my genitals here. I see high estrogen (55 pg/ml with normal <30) and i see a blocked 5-ar II enzyme with very low levels of androstanediol glucuronide. (1.28 pg/ml normal is 3.5 - 18).

I don’t understand why blocking estrogens shouldn’t give rise to T and dhT. Well i reckon today some doctors told me that it could block e2 efficiently but not increase T on the other side, so i will need something more specific.

Anyways, that’s my only problem- how to save my genitals. All the rest is better in my body- energy- i can have sex somehow with difficulty but i can still have and i have normal FSH, LH, average T wtf. But testes are continuously decreasing in size- no matter what i Take. And this shrinkage is steady in levels, it increased in severity as my estrogen levels rose. Before that i didn’t have issues with my testicles. It started 3 years ago when i started experimenting with bringing T levels up then my estrogen would bound to higher levels because T wouldnt metabolize into DhT. That’s the whole issue.

Unless there is some mysterious auto-immune disorder that i don’t understand off, or the ultrasounds don’t show. Plus i believe that high estrogens and low dht cause inflammation in prostate and surrounding tissues. How else would one explain the pains in my testis and surrounding genitals??

Many of us had these pains, can you explain it otherwise apart from having a serious hormonal imbalance???

I understand that the issue is more complex, and maybe neurotransmitters are not working efficiently to keep a proper balance in my hypothalamus regarding the generation of GnRH, CRF,TRH etc etc and this is why probably most drugs after finasteride don’t work properly, or maybe its due to the weak effect of cortisol on its receptors or the low adrenal reserves. Low adrenal reserves or distorted HPA may cause significant imbalances in hormonal treatments. But in no case should we run totally away from correcting some obvious hormonal problems.

Wtf, is there any other situation in this world apart from high E2 that could cause gynecomastia and shrinkage of the testicles??

See my pm.