SSRIs and the wrong reaction

I’m not a doctor but I would not cut your dose in half. If it were me… I would go from 30mg to 22.5 for a few days just to see how I feel… then down to 15mg. Cutting a dose in half seems like a big jump. You should consult your prescribing doctor on lowering your dose safely.

BTW… what do you mean you crashed on KAVA? What was the crash like?

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Thanks for the advice shellnyce, I’ve only taken 3 tablets so the dosage isn’t established as yet, if I’d been on it longer/reliant I would be more conscious of a sensible taper. I’m relieved at getting some sleep and hopefully 15mg will provide the same result. Appreciate the input from this forum as always :slight_smile:

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To be honest, if you can swing it ( I know this is the opposite of what I just said) try to get down to 7.5mg as your dose for sleep. That gave me the best results for sleep… eventually I built a tolerance and had to bump it up to 15mg. I would avoid going over 15mg for long periods of time because once you are on a higher dose than that, you need to taper your dose back down if you ever want to get off of it to switch to a different sleep aid. The problem is while your tapering down… your not getting sleep. I’m on 15mg right now and its not quite as effective as it used to be 4 months ago. So rather than try upping the dose… I am considering switching to Trazodone. From what I have read, I can safely switch from Remeron to Trazodone without a taper. Once I’m on Trazadone… I could theoretically raise the dose of Trazodone as needed. You CAN NOT take Trazodone and Remeron at the same time because they both raise serotonin. You can risk what is called serotonin syndrome and it is really horrible… nausea, headache, sweating, heart palpitations, and in extrememe cases people have died from it. You can take Klonopin while on Mirtazapine but that is a can of worms because you risk building a dependence on it. Anyway… thats my amateur advice. If you have only been on mirtz for 3 days. Drop straight down to 7.5mg and you will probably get an excellent night sleep. Just listen to your body and talk to your doctors.

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Cheers. I’ll drop to 7.5 from tonight. Overall and so far I’ve had approx 5 hrs sleep per night since starting (equiv of hibernation lol) woke this morning in a relatively good mood and able to context issues I also had an 18cert dream. Good early signs let’s hope it lasts and doesn’t result in a crash like everything else will keep up posted

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Hey @LazarusRy just thought I’d check in to see how your doing with the Remeron and other things. As I mentioned I seemed to have built a tolerance to Remeron. I’m currently on 15mg. I asked my sleep Dr. to switch to Trazodone and she gave me a rash of shit about switching drugs and wont allow it. She old me to bump the Remeron up to 22.5mg (a pill and a half) . I may try this but even if it works I fear its not sustainable and that I will be trying to titer off something that doesnt work at all and suffering zero sleep.

In other news… I bought some Green Roads 550mg CBD oil. I heard from another user @Mcbbould that CBD oil really helped him sleep. I have no idea what dose to take though. Any suggestions would be great. Cant believe how expensive this stuff is. One little bottle was like $85 . If I could use it twice a week to supplement that would be great.

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Hello again Shellnyce,
I’ve had a little more sleep, suffered more sweats, louder tinnitus, greater social anxiety, even dryer skin and increased neuropathy. Going to give it another week to see if things settle down. What we’ll go through for some shuteye. Tried traxadone prior to Xmas and it blew me out of the water. Was on to crisis line with suicidal thoughts so parachuted it immediately. Keep us posted re the oil, would be good to hear cheers

Wow… did the Trazodone give you suicidal thoughts immediately or did it take some time. I had a similiar experience with Ambien. When I first tried it , it left me crushed the next day. I was very lucky to have gotten a script for Remeron quickly because I was having some really dark thoughts.

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Got about 5 hrs shut eye but ready to end it the next day everything PFS wise went through the roof though I was going insane! Laster for days

Hi 2981 can you remember the doses you used for melatonin and other natural supplements? How soon after your crash did you take these?
I came across this site they may offer online support, good info.

Baylor is going to announce in few weeks in theory. Let’s see, i feel hopeful.

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I wouldn’t hold my breath…

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Hi ac3c,

Prior to full blown PFS I used to take them intermittently and as per the dosage on the bottle “can’t remember” but that used to do the trick. Sleep inducing foods used to also work well or turkey, lettuce and cherries for the foods, amounts were the equivalent to fill a hand. I only tried melatonin post full blown and it brought on unpleasant symptoms
Ie night sweats worsening of cognitive symtoms. I had the same issues with 5htp. However some guys benefit from this. I’d give the turkey a try first but do cycle with maybe the cherries and lettuce one one or two of the said supplements. Good luck mate

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The sleep link looks pretty good/informative

Kava may Reduce Growth of Prostate Cancer Tumors

Flavokawain B reduces prostate tumor growth, in part by reducing androgen receptors in prostate cells in mice and cell studies. Flavokawain B also kills tumor cells by activating the pathways that cause cell death (caspases and Bax)

Kava Components Down-Regulate Expression of AR and AR Splice Variants and Reduce Growth in Patient-Derived Prostate Cancer Xenografts in Mice

ssri made me suicidal and also had no effect on my condition

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Same here

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Did you find 5 gaba agonists to cycle with? Have you tried fermented foods to build up GABA? I rarely spasm when on these but when I stop the spasms increase.

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Gaba worked well for a while, prior to me realising I had PFS. Tried fermented food but only got benefit from a single serving. Can’t take either now as they cause an unwelcome heightening in symptoms

I took GABA 750mg and it gave me really scary air hunger. I havent taken it since. I drink Kombucha from time to time. I take a probiotic and eat yogurt from time to time. I think the solution are all the precursors to GABA. The brain needs to heal for these to work properly. I take a very high quality fish oil and try to meditate for at least 20 minutes every day. I think this may take a long time but will ultimately fix my neurotransmitter issue.

Anything I take to stimulate GABA causes a sex hormone crash. The worst crashes cause my libido to skyrocket for an hour then the next day my hip hurts, pure damage. I’m taking EPA fish oil once a day. I most likely need to fix my neurotransmitters too so anything you can recommend would be appreciated.