SSRI only indrectly antiandrogen?

Therapeutic Efforts Pharmaceutical
#1

Hi,

i want to try low dosing SSRI for boosting ALLO levels.
Is it true they act antiandrogen only indirect over 5-ht?
So a dose too low to affect sert should be safe, right?

#2

Even low doses were found to have a profound effect on steroid metabolism:

G. Pinna, E. Costa, and A. Guidotti, “Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake,” Psychopharmacology , vol. 186, no. 3, pp. 362–372, Jun. 2006.

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#3

Yes that’s the effect i’m looking for.
But in the theory SSRI being antiandrogenic it’s mediated by 5-ht?

#4

It also affects an enzyme called 3a-HSD. Inducing 3a-HSD increases neurosteroid levels and decreases cellular androgen levels, so I’m afraid this is also risky.

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#5

Not a theory, has been confirmed by various studies. I would not touch AD’s with a 10 ft pole in our condition. Actually I had at the beginning of my PFS odyssey, various kinds, and they all ended up worsening my condition.

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#6

Ok thanks guys.
The studies showing antiandrogenic effects have been done on ‘normal’ doses.
So you think they are still antiandrogen at low, non serotonerg dose?

#7

I don’t want to take things off topic, but just wanted to ask quickly whether or not anyone knows if topical Retin-A would be dangerous? The quantity of Tretinoin actually involved would seem negligible compared to that of oral Tretinoin (Accutane), but worth asking.

#8

Happen to have links to these studies?

#9

I’ve used retin-A a little while ago, being sure to apply as little as possible to trouble spots. I didn’t notice being any worse off afterwards.