While i was browsing the web, i found this interesting article:
wipo.int/pctdb/en/wo.jsp?IA= … SPLAY=DESC
If this article is already available in the medical research section then
The binding of androgens to the androgen receptor is also important in many androgen related diseases and conditions, such as baldness and acne, as well as important clinical diseases such as prostate cancer. The androgen receptor belongs to the steroid receptor super family that plays an important role in male sexual differentiation and prostate cell proliferation
This we all knew already, but the following is interesting:
ARA70, which is a co-activator for the androgen receptor in human prostate cells. The ARA70 factor is a ligand dependent protein that functions as a specific co-activator to enhance the transcriptional effect of androgen binding to the androgen receptor and also facilitates binding and activation of the androgen receptor by molecules previously not thought to have androgenic character.
Another Quote:
The theory for such measurements of relative ratios of ARA to ARA70 is that androgen insensitive related disease may be due to an imbalance between androgen receptor and androgen ARA70 prevalence in target cells. Too much ARA70 might over-sensitize the androgen receptor system, so as to be responsive to molecules not intended to have androgenic effect. Under sensitivity due to absence or non-function of ARA70 may lead to androgen insensitivity at any levels. If too much ARA70 was found to be present in a particular patient, that would suggest the use of down regulation mechanisms such as antisense or other similar mechanisms, in clinical system so as to reduce the levels of ARA70 prevalent in a particular patient. If a particular patient had too little ARA70, then it would be possible to deliver ARA70 cDNA, protein, or DNA, into a patient by a variety of delivery mechanisms to increase levels of active ARA70 in the patient."
How ? and where it could be done ? i don’t know but at least it gives
