I have taken these paragraphs from a discussion elsewhere on the internet. Considering this guy has studies as a cell biologist and has a pretty good theory, i thought i should post it up.
“I studied as a cell biologist. Both will massacre your prostate especially Dutasteride which inhibits the adrenals as well as the testes. The prostate contains secretary epithelial cells which produce semen (mixes with spermin) the lack of DHT causes these cells to degrade and commit apoptosis (die!) so you have a vastly reduced ejaculation, if that isn’t bad enough the prostatic smooth muscle cells will atrophy meaning very weak ejaculations (when you ejaculate these muscles contract) as does the ejaculatory ducts leading into the urethra which narrow and will lead to BPH. Should you come off it (5-alpha reductase inhibitor/GnRH) normal testosterone levels will resume except your prostate is now functionally fucked and you lose your hair anyway. I did hear about people taking growth factors (IGF-1 among others) to restore prostatic health (through repopulation) and improve sexual function. Just speak to an endocrinologist… NOT a urologist as you end up a remorseful balding retard who can’t fuck while lining the pockets of big Pharma.”
"From an endocrinological perspective Dutasteride will involute the prostate by messing with the hormones levels making it smaller. Usually this takes place over many years where the prostate atrophies very slowly over time through what they call male menopause (andropause), this is contraindicated because while at the same time insoluble laminary secretions accumulate over time with prior sexual activity, as sexual function declines the prostate will have little to no means to expel the prostatic secretions causing the prostate to enlarge impairing urinary flow leading to what they call obstructive uropathy, basically the prostate slowly calcifies turning nodular.
Dutasteride is purely for symptom control, correct it will accelerate the atrophy of epithelial cells making the Prostate smaller which can improve the urinary stream but it’s symptom control effects are only temporary. As soon as you come off it… and over time the seminal vesicles/epithelial cells become more hormone efficient (refractory)… the now useless prostate will then enlarge from prostatic secretions which you are now less able to expel as background testosterone levels rise, and from the repopulation with prostatic basel cells (not epilithic) most likely from dietary growth hormones as found in dairy products. What they call the Gleason score is a measure of cellular distortion and function not aggression (Cancer mongering hype) but this is liable to be higher as well. But yeah BPH is more a measure of urinary flow complication rather than overall volume.
Look at Klinefelter’s syndrome patients who have few prostate issues because of low level background testosterone, usually presenting an atrophied prostate and sexual dysfunction (they might as well be on Dutasteride), as soon as they have testosterone supplementation, problems."