You seem to have a leaky brain barrier. It’s not unusual at all and GABA supplements are used to verify if it’s the case or not. L-Tyrosine is not for everyone. If you don’t feel good with it, stop it. 5-HTP won’t solve the real issue which is IMO excess Glutamate. A pinch of MSG (mono sodium glutamate) instantly gives me anxiety.
I’ve seen this is many PFS sufferers including myself. The Androgen Receptors have been up-regulated (or over-expressed) in response to an androgen deprivation therapy (Fin). This is not from me, it’s from one of the researches from Dr. Roberto Cosimo Melcangi in Italy. He says AR are enlarged and oval shaped under the microscope.
I’ve read in another study that the AR are regulating the L Glutamine complex in the body. Over-expressed AR is said to create Glutamine complex toxicity, that is, too much of the Glutamine metabolites in the body. One of those metabolite is Glutamate which we end up having in excess. It’s the excitatory neurotransmitter that should transform into GABA at night to provide good sleep. For some of us, not enough Glutamate is transformed into GABA and we don’t sleep very deep or at all. Over the night, testosterone level goes up (as in all men). That makes our AR produce extra Glutamate at night and we wake up fully awake and lit up, as if we just drank 3 espressos.
There certainly has been many epigenetic alterations to counter-balance the excess Glutamine complex metabolites. In my opinion, to try and find them all is maybe educational but it misses the point. The initial problem is having been deprived of androgen and 5ar which has caused the AR to be over-expressed in order to capture what little androgen was present. I believe in putting the body in a state where epigenetic repairs can take place and then signaling to the body which direction it should take. For this, I’m fighting an androgen deprivation therapy (fin) with an androgen supplementation therapy (not TRT). It has made some long gone symptoms reappear but they are now receding. Sensitivity is much better, sleep is better on half the sleeping drugs compared to 2 years ago but I won’t know the final results until I stop the supplementation and let my androgen come back to normal. By then, I hope my AR will have adapted to higher androgen levels and normal ones will produce normal results. Let’s see.
I don’t suggest anyone try this. I’ve worked many years to make my body stabilize and my symptoms were almost all gone before I was strong enough to get worst. It still remains to be seen if I will actually get better from this. I’m a guinea pig in this experiment.