Sleep disorder


Can anyone tell me why Propecia can cause sleep disorder. Since I took Propecia I couldn’t sleep well. I think I never had any deep sleep phases (REM phase).
Thanks for any thoughts.

  • Impairment of GABAergic system in the brain due to loss of 5AR-derived neurosteroid synthesis (Allopregnanolone/THDOC) while on the medication. GABA-A receptors/GABAergic system are involved in REM sleep.

  • Decreased nitric oxide synthase. DHT has been found to mediate nitric oxide, and Finasteride inhibits DHT. Nitric Oxide is involved in the sleep/wake cycle.

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Thank you very much Mew. Great to have such a dedicated forum member like you.
All the best.