Signs of metabolic syndrome

Looking through these blood tests, I noticed a pattern which was fairly common:

  • Raised triglycerides
  • Reduced HDL cholesterol
  • Raised fasting plasma glucose
  • Complaints about increase in midsection fat

These are the basic ingredients of what is called the metabolic syndrome:

en.wikipedia.org/wiki/Metabolic_ … #Diagnosis

Testosterone (and thus the androgen receptors) play a central role in this:

ncbi.nlm.nih.gov/pubmed/20126841

Awor, interesting observation. For me:

Raised triglycerides - not an issue

Reduced HDL cholesterol - this seems to be getting worse, even though overall cholesterol is pretty low. HDL/total ratio 0.2

Raised fasting plasma glucose - borderline high all years post fin until I got on regular T treatment (topical T now low dose clomiphene)

Complaints about increase in midsection fat - Guess that did happen post fin (been off for several years) does seem like it takes considerable attention to diet and exersize to keep it a non-issue (currently).

Couple of other common themes I see:

Low 25 OH Vitamin D (I think because something about post fin causes high rates of conversion to 1,25 Vitamin D active metabolite, my own tests show this). Vitamin D Receptor gene (VDR) is part of the same family as the androgen receptor genes.

Low FSH that does not repond as it should to clomiphene. Eventually, as others start testing, I think the low FSH group will all show high inhibin B.

kazman

Awor, kazman any further thoughts on this?
This could be a piece of the puzzle.

My cholesterol hdl is 1.04(>1.01)
Low to start and i suspect getting lower. I will have a test this week to confirm.
I have a strong suspicion we are not absorbing fat via a problem with the bile, pancreas, gallbladder…somewhere in that region.

tim,

what is your LDL?

Im at 1.4(0-2.4) for LDL CALC estimate(looks like a different test from a direct measure of LDL).
Im going to the doctor in the morning will jive for direct LDL measure.
Also Kazman check out my vitamin E deficiency 16 (23-70)

We obviously have metabolism issues, thanks for pointing a finger at this. Fin altered our liver enzymes, now the question is what to do about it?

Martin im not sure it is a liver problem, although i have read storie of fin causing acute hepatitas. There is stories floating around possibly linking finasteride to acute pancreatitis. I will be seeing my doctor tomorrow and focusing on this. Gallstones that are blocking bile flow is also a candidate. For me fat absorbstion is the problem, but i cant prove it yet.

Fat absorption IS a liver problem.

By stating what your problem is but saying you cannot prove it yet you will lose credibility if it isn’t. You should hold such judgments until waiting for a cycle, for me it could take months before I realized a supplement wasn’t going to be the cure all.

How are you doing with zinc?

You were right about the zinc, my body couldnt process it. Which is a problem in its self as my blood test showed a deficiency.
Fat absorbtion can be but is not isolated to being a liver problem.
Credibility, haha, you know i have non of that :smiley:

Martin the liver is responsible for making cholesterol, which is what you are talking about?

Fatabsorbtion. Adrenals ring a bell?

jbc.org/content/140/1/241.full.pdf

Kazman, i saw the doctor this morning. He disregarded cholesterol tests for the moment after i told him about my urine and stool quality, instead i have a liver, biliary tract, gallblader etc ultrasound for the morning. He also ordered a amylase test, did a quick search of prophelp and didnt show up, possibly a different name in other countries, pancreatic function test by the looks(among other things). The doc also reordered another c-reactive protein test(last time out of range high), liver function(has been coming back normal to present) and vitamin k(at my request).

If this fails i have a date with a GI tract specialist.


Troubledfinuser, this is great information and definantly worth more than a consideration it is on my checklist. First up is bile, in terms of fat breakdown, which is of course before absorption. Cheers

Same problem here guys. Low total cholesterol, low hdl, zinc issues. I took some digestive enzymes with a meal and a 15+ chelated zinc sup yesterday and actually had hair shed in my hands this morning when showering. First time in awhile. Beard grew a little more than usual as well. Could be coincidence though.

Just to be clear I started taking the digestive enzymes the other day when I first heard you guys talking about fat absorption issues. Didn’t know if it would help and still don’t.

I don’t know about fin but read about betasterole (on pubmed) that it binds in intestine ( to what sites I don’t remember actually read long ago) so that low fat is absorbed (that is why used in margerine). BS also binds to leydig cells and low cholestrol converts to testosterone. It looks like it binds in such a way that it destroys cells over there. We stopped them and still low TT and low cholestrole. sorry guys I don’t have study with me