I’m in the same condition as you I think I have Kennedy’s syndrome maybe or receptors already very up and that’s why I lost a lot of hair finasteride deprived them of DHT further up regulated this causes toxic hormones that damage muscles and nerves with replacement of soft matter everywhere unfortunately there are no cures. Did you find anything?
I think some people like me for example can have a genetics very similar to Kennedy syndrome I have always been with very thin legs and genitals not very virile let’s say so. Those who have this base tend to have receptors that overexpress themselves to compensate for androgenic deficiency, this leads the receptor to toxicity. Finasteride amplifies this over-expressing effect even more the receptors that produce greater toxic hormone that causes muscle damage similar to ALS, persistent depression, increased body fat, erectile dysfunction. Depriving yourself of hormones slightly overexpresses the receptors even more increasing testosterone increases the production of toxic hormone that is why the drug at a certain point is no longer tolerated and taking exogenous testosterone creates damage. In people with a normal base, the body eliminates toxic hormones and regularizes within a few months, maybe a year and a half and two. In people with a poorly androgenic basic genetics, hormonal toxicity becomes chronic and the body cannot promptly dispose of the toxicity that accumulates, thus suffers damage, the muscles are reduced, the androgens no longer exert their anabolic function. This is my thought but in any case there is no way to detoxify the body and take hormones that work. Those who did not recover in my opinion were seriously hypogonadic from birth as in my case and probably in Lok’s. It is known that the Chinese have low DHT this leads the receptors to overexpress themselves finasteride has done the rest … It would be interesting to understand how he’s been writing for a year I’m exactly like him
Hello,
I recognize myself in this situation. however, from what we know from research, AR overexpression has epigenetic characteristics and can theoretically be reversed. In the treatment of prostate cancer, the solution with hdaci has made its way to desensitize and degrade the overexpressed receptors. I invite you to consider (perhaps learn more with chatgpt) the use of sulforaphane in these contexts. I can report my personal experience which is absolutely not intended as medical advice. I have been taking sulforaphane on a regular basis since November and I have almost completely recovered my muscle mass, my pubic and armpit hair has grown back and I have nocturnal erections again which had disappeared for years. The intestine seems healed. There remains widespread inflammation and tendon and muscle pain that resolves only with anti-inflammatories. Consider that I had arms like a skeleton and legs with holes. I’m a pretty serious case too. A hug to everyone.
Where can I find this sulforaphane? What dosage did you use?
I’m sending you a private message, because I don’t think specific treatments can be recommended in posts. But first I wanted to share an answer that chatgpt gave me about it, so that anyone can form an idea for themselves:
Of course, here are links to scientific studies that support the effect of sulforaphane (SFN) on androgen receptor (AR) regulation in prostate cancer cells: Transcriptional repression of AR by sulforaphane: This study demonstrated that SFN treatment causes a dose- and time-dependent reduction in AR mRNA and protein levels in LNCaP and C4-2 human prostate cancer cells, indicating repression at the transcriptional level. Destabilization of AR via HDAC6 inhibition: Research has highlighted that SFN inhibits the activity of histone deacetylase 6 (HDAC6), leading to acetylation of the chaperone protein HSP90. This process impairs the interaction between HSP90 and the AR, promoting the degradation of the AR via the proteasome. Reduction of AR protein levels and synergy with anti-androgens: One study showed that exposure to SFN rapidly decreases AR protein levels in a dose- and time-dependent manner in LNCaP and C4-2B cell lines. Furthermore, SFN increased the efficacy of anti-androgens in suppressing cell growth and prostate-specific antigen (PSA) expression. These studies suggest that sulforaphane may modulate androgen receptor expression and stability through epigenetic and post-translational mechanisms, making it a potential therapeutic agent in the context of conditions associated with AR overexpression, such as post-finasteride syndrome (PFS).
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My legs are completely gone my skin hurts easily even by passing a towel on my wet forehead is anyone like this?
Yes I have it like this so does Lck he shared photos with me a few years ago. A few other do too.
On a positive I had a window from Tocilizumab it all returned to normal but sadly it fell away but it does tell me that it is reversible. This type of wasting hit me in 2017 so know it will not end your life despite the effect it has on you both physically and emotionally. My knees are a lot more creped /saggibg like an 80 tear old grandma…
Oils and fats seem to be the most damaging… which are big hitters 5ari wise
but lplant food sources are also 5aris which I react to badly…
One additional point I also had long term exposure to minox. More so in the latter part of my 5ari drug usage.
Collagen degradation is more prevalent in their community.
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My hands look like yours. What’s wrong with them?
thy burn and turn red for everything
Mine do the same thing, I also get it on my feet and legs, a bit on the chest too but only after a shower. The hands redness and occasional slight burny feelings happen all the time though. I can’t find any known cause of it. Changed soaps, other skin care products, all different types of diets, it’s one of the most persistent. Nothing seems to touch it.
I lost all the muscles of my body I’m inflamed and full of pain everywhere I feel like Lok like one with slas is the more I try to exercise the worse nothing flame nothing improves. The hands and knees are constantly burning the skin of the face is red and easily injured I didn’t think finasteride could cause this!
Also for me last year it started in February like flushes after the hot shower then from August it became a constant burning with pain muscle loss and weakness there is no remedy I tried everything to recover muscle but nothing works I am like a 13-year-old child physically. Nobody believes in finasteride and I too begin to falter in this conviction even if I have to say that I took it for 23 years
I wonder then if having that means we’re prone to it happening but it doesn’t progress in all cases to the pain and muscle loss. I also have flushing attacks but if i keep my diet in control they tend to minimize themselves at least. I’m sorry for what you’re going through and can only hope in the future the medical field finds out what this condition really is.
I think my mitochondria are severely damaged by now and there is nothing that helps me the inflammation is very strong I am really hopeless I let my body be destroyed little by little now it no longer responds to anything I am consuming myself from the inside
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