Evidence??
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can you prove pfs? or have you seen someone who can prove that you want proof from me? If I could prove it, I would be talking about this issue in the world health organization, not here. time to go! time to research! time to read! time to using your brain! If your aim is to find evidence, you are in the wrong place. you must be in the lab. we know there are those who claim to have recovered from meditation. we are also talking about the claims naturally.
That’s a massive article mate , do you know where the exact serotonin and finasteride reference is in there?
you can try ctrl+f and write serotonin my friend.
" In the future, the measurement of dopamine and serotonin levels in individuals with PFS may elucidate many issues, since the pathways of these neurotransmitters can be altered in neurosteroidogenesis disorders, which in itself would affect sexual behavior in these patients.44
The possibility that epigenetic mechanisms may influence the occurrence of PFS is also discussed, as it appears to affect a limited number of individuals exposed to the drug.44 Giatti et al. even raised the hypothesis that PFS has mechanisms in common with post-selective serotonin reuptake inhibitor syndrome, given the wide range of similar symptoms in the two clinical entities"
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Interesting …well that would explain the “feeling like shit in general’ thing that seems to hang over us all , if serotonin and dopamine pathways are messed up. So serotonin boosters should improve symptoms ? Perhaps not SSRIs for the risk, but maybe TCA’s or St. John’s wort , inositol, 5htp etc
i dont know. but i know playing serotonin is dangerous
It is??..if we are lacking in it surely boosting our levels back up would be a good thing and give us a sense of well-being etc
I think there may be a system failure rather than a deficiency. if there is receptor damage, it may be at 5-ht receptors, not androgens
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Ok…wow scary stuff eh
as far as serotonin increases, libido decreases
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I think the mods of this forum would have figured it out by now, if the association between these 3 syndromes was infact serotonin.
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is there a way understand serotonin system ?
…might explain why some Fin users feel good with alcohol.
They are reporting increased neurosteroidogenesis for rats where allepregnanolone was inhibited with Finasteride…It is astonishing this poison is being prescribed as a medicine.
The levels are altered and it must mean they can even be elevated. Both too high dopamine and too high serotonin is really bad, so possibly we can get better with decreasing one of these or both rather than increasing them to balance the levels
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how to reduce ?
I concur that. I’ve previously been on high dose Dopamine precursors (Phenylalanine,Tyrosine, L-Dopa) and while the increased motivation alongside uptick in libido initially felt great, I still felt depressed and sometimes overly stimulated. Too much Serotonin, on the other hand, made me melllow and put me at ease. That said, there were times when I experienced a balanced state and boy did it feel heavenly good.
Manipulation of neurotransmitters with precursors is a risky business. It’s better to look for damaged mechanisms and fix them.
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The opening post has been updated to emphasise that they are the opinions of the poster and the declarative statements edited. A reminder on theories and declarative statements
PFS is not yet conclusively understood and patients are in dramatically different conditions. Do not make definitive claims such as “PFS is this” or “Do this and it will cure you”. Instead, consider using language such as “I believe…” or “This has worked for me”. Please do not simply append “I believe” to a declarative post to evade this.
Contributions are most informative when they provide detailed accounts of personal experiences clearly separated from inferences or theories. If you want to hypothesise or speculate, please ensure that it is clear from your post that you are presenting your personal opinion and the basis for that opinion. Do not make declarative statements regarding the etiology of PFS, or assert things without significant and specific evidence. Take care not to present your thoughts in a way that could be taken as medical advice.
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Totally correct.
It will mess with orgasm delay as well.
I took 2 years SSRI, and now 2 months for dopamine and noradrenaline …
Ssri was not my solution … the dopamine antidepressant cant say yet ofc.
Greetings
I just came here and saw this post. I want to tell you about my experience past 1 week. I have experienced rock hard morning wood. The reason I am telling you about this is at night time when I am relaxed I get that rock hard but mow it stays the same when I wake up and 10-20 it is rock hard. the think is I noticed that it fades after 20 mins or so it has to do with some sort of mental relaxation/hormone. My guess is serotonin is part of the problem. I sleep more with deep sleep and I am relaxed I feel better as time sasses.
I would like to recommend natural way to relax your self. I am a big fan of Wim Hoff method.
This is the video to fallow. All it is 10 mins of breathing.
It has helped me so much and I feel happy afterwards. This is the best thing I have done for my sleep/mental well being.
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I think you are onto something
I seen that the amount of serotonin in my urine was below the optimal range. I increased natural serotonin production with 5-HTP and
L-Tryptophan. My constipation nearly went away. I retested and the amount of serotonin in my urine increased and was now in the optimal range. It turns out most of the bodies serotonin is produced in the gut and it stimulates intestinal contractions. To be honest I’m still thinking that I may have leaky gut syndrome and or altered gut bacteria. But it would be stupid to ignore the fact that I increased serotonin and my constipation of seven years went away
It’s guess work but I think in my case I have glutamate, dopamine, adrenaline and nor adrenaline issues maybe responsible for my sexual sides. I’m still experimenting with amino acids that convert to specific neurotransmitters attempting to figure it out. Playing with fire though because a cock tail of amino acids bask in November of 2020 caused a PFS crash like state of severe insomnia for me. This time I’m taking specific amino acids individually in an attempt to narrow in on specific neurotransmitters . Hoping I don’t crash again … I’m playing Russian roulette
Also if others got the urine neurotransmitter test we could try to find patterns in the amount of each neurotransmitter we are peeing out
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