sananes bloodwork after 4.5 years update

For me…this case show that to go into hormones has no sense…there is almost imposible to predict how improve your status based on T, DHT, E2, etc…

yes i wont touch drugs, i wont come here i think

1)https://www.nature.com/articles/35094009
2)https://www.medscape.com/viewarticle/467251

the pfs is this…

  • Androgen-independent prostate cancer (AIPC) is an untreatable form of prostate cancer in which the normal dependence on androgens for growth and survival has been bypassed. AIPC is selected for by androgen ablation therapy.

  • The potential mechanisms by which AIPC develops can be divided into five categories.

  • In the hypersensitive pathway, sensitivity to low circulating levels of androgen is increased by amplification of the androgen receptor (AR), mutations in the AR, increased levels of co-activators, or increased production of the potent androgen dihydrotestosterone. Tumours that use this mechanism continue to depend on both androgen and the AR.

Almost all prostate cancer patients become resistant to therapy that blocks androgen-mediated cell proliferation. The key to this resistance may lie in expression of the androgen receptor itself.

Most patients with metastatic prostate cancer receive drugs that block production of androgen, which promotes cancer cell proliferation. These drugs rarely actually cure cancer, however, because the initial response is almost always followed by a relapse to an unresponsive, hormone-refractory stage

Interesting post. I have posted a similar content.
This sort of cancer is not independent from hormones but rather reacting! to the different levels cause the maingoal is to survive.

Interesting as well is that this kind of prostate cancer can be killed with electrotherapy. Super interesting is that mutation! was listed in that study.

So, could we have a mutation re the AR?

any ways my doc said “its normal. what you can do?, which hormones you will alter? medicine looks for the problem, if hormones are too high and not working, in current condition hormones are low and working, its sensitive… its good thing and … its a miracle for you to have sex…and having a libido”

??? What is normal? I don’t quite understand the post.

I think you have a great reacting body. Very interesting. Once again: it shows sexual behaviour is not depending on absolute androgen levels but rather how the interplay between AR etc. and androgens is (how sensitive are someone’s AR?) So your body regulated himself into a certain equilibration level.

PFS can be a lot. It depends how your body was before (sensitive to androgrns or not) and how your AR reacts to dht deprivation and uprising levels.
That’s why I would like to see blood work of ppl on fin and not just post fin.

Anyway, congrats to your progress. If I see a guy walking with a boner in his pants, it must be you. :slight_smile:

I have read awor’s and mew’s theory. If its true, it says gene silencing, insensitivity etc. I think i am at overexpression level of this chart. i lost muscle mass recent years as stated

What do you think of this is that still legit theory?


http://www.protocol-online.org/forums/uploads/monthly_07_2010/msg-19273-074754700%201280151401.ipb

As I said I do not believe in that androgen independent theorie. It should be: Despite androgen (partially) deprivation, c.cells grow.
So, whether they are extremely over expressed in order to run “properly” as those cells want to survive. C. is somehow a survival program. Anything that disturbs the normal cellular metabolism will cause that program in order to survive.

Now to the theory: I read whole the theory several months ago and I agree in most of the points. What we don’t know if everybody on fin has AR overexpression. We need to test this!
If so, what cag repeats does he have? I guess the longer ones. = ppl with higher androgen levels due to a greater insensitivity to androgens.

When this ppl get androgen deprivation, what happens to their lower sensitivity? Correct, they get AR upregulated in order to get androgen pathway running. That is the goal.
Test doesn’t decrease on fin, it even gets higher. But E2 gets higher as well. So, you get a puffy face, feminine face. E2 is trying to inhibit fin. Here we we are.

You have upregulated AR. I even guess you had bigger muscles and big energy while on fin, but also weight, gain, right?

I want to study your case a bit more. That’s why it would be interesting to have some other parameters.

I will come back here after reading your posts.

Cheers

Yes i was 88kgs and puffy when on fin now look like more lean face johnny sins type body :slight_smile: without muscle 73 kg. the key is foods or any food intake directly plays with AR. and push those very sensitive receptors over their recepting limits and makes them insensitive. dont eat anything you will see the sensitivty. especially salt and sugar

Very interesting. The for the hint re nutrition. Very useful for me.
Water fasting could help some ppl with upregulated AR and high testo levels. Let’s see.

another test… after 1 week… nothing changed in diet and no drugs only daily sex with different girls… :slight_smile:

it has doubled in one week i dont know how and why?!
maybe that day previously i was erected when i see two girls in front of me waitng on bloodsample line… that is dropped the T?

Sex can raise testo or nofap for seven days.
You are already testing, so I would try nofap for seven days (highest peak of testo) and let testing. That would be interesting.
Forex: Day one after! fap test testo and other hormones like prolactin etc., then nofap/nosex for 7 days (I know mission impossible) and then retesting. That would be cool seeing how you feel!

You would profit from the tomatoe juice protocol I guess in order to have different girls on one day. :slight_smile:

and third test… its after 3 days after second one…

interesting…

no drugs

nothing

only paleo

now theories not legit for me. i wish all pfs is temporary or BS. :smiley:

I dont understand exactly your lines. Would you mind giving a hint.

What about your HGH and DHT levels?
Could you measure them as well?
Thx

no more tests i will abandon ph.com for some time.

Oh, what a pity. No dht levels?

:smiley: hahahah yesssssssss; i have banged a blonde tonight,awsome ,

Okay. But what about your dht levels. The blonde is not that important. Sorry.

Is this the next bs cure story?
Low testo etc. but no dht levels when asked for?

Coming back after 4 years to tell such stories?

Well paid.

Every guy coming back after several years is just not credible. Period.

dht is most likely will return normal/average levels. because e2 is average t in average and shbg little high. djt cannot be tested in serum because all in prostate etc tissues has it.

i wish pfs is a BS.

Hormons can be very well tested in serum (blood) I am afraid, I don’t believe you a single word. I am out here.