I am surprised that no one has posted about this supplement yet. Based on my research, it sounds like it could have positive effects in alleviating some of the mental and cognitive issues that occur with PFS.
Not only does it help regulate neurotransmitters, but it also has a positive effect on liver health and reducing inflammation. There are some theories floating around this site that some of the issues may be caused by inflammation (and therefore that us why ibuprofen helps many), and also quite a few posts about liver function playing a role (see milk thistle ideas). Sam-e seems like something that may contribute to all three areas, so I figure it is worth a shot!.
I started taking 200mg twice a day yesterday. Supposedly its benefits occur much faster than many prescription antidepressants, so I will keep everyone updated over the next week or two.
Here is some additional information.