This drug won’t be a “cure” for PFS in general. That is clear. For example, in all likelihood it won’t address physical changes like dry skin, muscle loss etc.
The hope surrounding this drug is related to the fact that it increases Allopregnanolone, an important neuro-active steroid. It has been demonstrated that people with PFS and mental symptoms have signficantly reduced Allopregnanolone levels compared to healthy controls. And there is quite a body of literature that shows correlations between low levels of Allopregnanolone and mental disease (e.g. depression, anxiety etc.) . Thus, there is some hope that Sage-217 may alleviate some mental symptoms of PFS.
As said above, there is no indication that it will do anything for physical symptoms. It is also worth noting that not only Allopregnanolone levels are altered in PFS patients, but also those of other neuro-active steroids, their precursors and metabolites. There is a lot going on. Also, there is quite variety between PFS patiens in mental symptoms that cannot be explained by low Allopregnanolone levels alone. Thus, it is unreasonable to expect Sage-217 to cure everyone from all mental symptoms.
It is worth keeping expectations in check. There is a chance that Sage-217 may alleviate some mental symptoms in some patients. That would be progress. And it is worth keeping an eye on it. I certainly will. But I would not have much higher expectations beyond that. For a cure, we have much much more work to do. That’s why everyone needs to support the ongoing and future community projects.