Replacement of Allopregnanolone with a synthetic hormone may lead to a suppression of the natural hormone. The body will detect the synthetic version then may decide after a period of 14 days that there is enough of the hormone within the body and thus stops natural production. Therefore cycling the drug for 14 days then coming off maybe a way to minimize the risk of damaging natural production assuming what I write is correct. So this drug may only provide a short term solution via cycling but still it should improve the patients quality of life during treatment.
With anabolic steriods a 6 month shut down of natural production is enough to damage the HPTA and result in lower levels of natural testosterone being produced on a permanent basis. The longer our natural production is shut down the greater the risk to natural secretion within the body. There is no guarantee that the body will accept a synthetic version over a long period of time. TRT patients have sometimes found testosterone treatments have started to fail after many years of use and require a long period off the medication.
We also don’t know how PFS will react if Allopregnanolone is introduced to the body at normal levels or what will happen to PFS if we come off synthetic Allopregnanolone. Then there will be a period of low natural production as the body restarts secretion.
The hormone system is a carefully balanced orchestra we don’t know what affect a synthetic version will have on other hormones or functions of the body. An example would be how synthetic testosterone can thicken the blood and increase risk of a clot formation. An Endocrinologist would probably have a better idea as to the suitability of this medication over a long period and the potential side affects to natural production. If anyone here is visiting an Endo it might be worth asking during the consultation what their Drs thoughts are on synthetic Allopregnanolone.