Sage 217 clinical trials started

General Discussion
#21

It is doubtful any endocrinologist, outside of neurosteroid specialists, could answer this. If they would even have an answer. Feedback mechanisms of allo may have never been investigated.

There is some back-coversion of allopregnanolone to DHP, which acts on progesterone receptors. But sage-217 is only similar to allopregnanolone, so it may not undergo a similar conversion to a DHP equivalent, or the metabolite may be inactive.

Someone else said that perhaps the drug is proposed to be administered in cycles because of a potential for tolerance or shutdown.

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#22

i thought it was proposed for long cycles because it was designed as an “anti biotic” that keeps the symptoms away for a long time

thats what i read on the sage websites and papers

#23

In addition to Sage, there seems to be another possible treatment for the depressive sides, which hopefully won’t have more compounding sides of its own:

The active ingredients of ketamine, a popular club drug, show promise in battling deep despair.

#24

will they reach their goal to finish SAGE217 trails by end of this year?

1 Like
#25
#26

Just an update:

“Jonas wrote the first-ever book about Prozac, called, “Everything you need to know about Prozac,” partly in reaction to a colleague’s negative article about the drug”

https://www.bizjournals.com/boston/blog/bioflash/2015/06/five-things-you-don-t-know-about-jeff-jonas-ceo.html

How much can we trust a guy who feels positive about Prozac? (Feel free to correct me. I haven’t read his book on Prozac)

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#27

Also the price of the drug is insane.

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#28

I’m moving to Salt Lake City from Australia soon, but it seems the closest trial would be LA. Does anyone know if you need to be a US citizen to apply?

#29

Sage 217 (Zuranolone) should be cheaper than Zulresso (Brexanolone), not sure by how much.

#30

This is probably up to the individual center or researcher conducting the trial. I wouldn’t imagine it would be a huge problem so long as you have a visa that is valid for the duration of the trial.

Myself and a friend applied for the last round of Zuranolone trials (I was rejected for some reason and she wouldn’t commit to the travel burden required at the risk of being given placebo).

There isn’t much work involved in applying. You could complete the online forms and see what happens

#31

Thanks - there’s actually a trial in Vegas which isn’t too far, but I’ll apply and see.

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#32

Anyone update on Sage ?

Are they still trying to bring their allopregnanolone drug to the market ?

#33

Zuranolone officially FDA approved.

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#34

Any word yet on how much Zuranolone will cost patients ?